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    K07B1.4 Acyltransferase [ Caenorhabditis elegans ]

    Gene ID: 179314, updated on 12-Jun-2024

    Summary

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    Gene symbol
    K07B1.4
    Gene description
    Acyltransferase
    Locus tag
    CELE_K07B1.4
    See related
    AllianceGenome:WB:WBGene00019464
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in body wall musculature; intestine; and rectal gland cell. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See K07B1.4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    3
    Sequence:
    Chromosome: V; NC_003283.11 (9328970..9331527)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene NOT2/NOT3/NOT5 C-terminal domain-containing protein Neighboring gene Phospholipid/glycerol acyltransferase domain-containing protein Neighboring gene UnCoupling Protein (mitochondrial substrate carrier) Neighboring gene Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in triglyceride biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Acyltransferase
    NP_505413.1
    • Partially confirmed by transcript evidence
    NP_872180.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9328970..9331527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073012.6 → NP_505413.1  Acyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O01881
      Conserved Domains (1) summary
      pfam03982
      Location:54 → 349
      DAGAT; Diacylglycerol acyltransferase

    2. NM_182380.8 → NP_872180.1  Acyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_872180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86FS9
      Conserved Domains (1) summary
      pfam03982
      Location:44 → 339
      DAGAT; Diacylglycerol acyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    T15251.1

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