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    Y47D3A.14 CMP/dCMP-type deaminase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176551, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Y47D3A.14
    Official Full Name
    CMP/dCMP-type deaminase domain-containing protein
    Primary source
    WormBase:WBGene00012927
    Locus tag
    CELE_Y47D3A.14
    See related
    AllianceGenome:WB:WBGene00012927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable catalytic activity. Predicted to contribute to tRNA-specific adenosine-34 deaminase activity. Predicted to be active in cytoplasm and nucleus. Is expressed in pharyngeal gland cell and pm7. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with brain abnormalities, poor growth, and dysmorphic facies. Orthologous to human ADAT3 (adenosine deaminase tRNA specific 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Y47D3A.14 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    6
    Sequence:
    Chromosome: III; NC_003281.10 (11235581..11236868, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Elongation of very long chain fatty acids protein;Very-long-chain 3-oxoacyl-CoA synthase Neighboring gene AcidPPc domain-containing protein Neighboring gene Association with the SNF1 complex (ASC) domain-containing protein Neighboring gene ncRNA Neighboring gene Ribosomal protein S6 kinase beta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CMP/dCMP-type deaminase domain-containing protein
    NP_499445.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11235581..11236868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067044.5 → NP_499445.2  CMP/dCMP-type deaminase domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499445.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NAH8
      Conserved Domains (1) summary
      cd01285
      Location:164 → 251
      nucleoside_deaminase; Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a ...
    Nucleotide Protein
    Heading Accession and Version

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