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    tmem-131 Transmembrane protein 131 homolog [ Caenorhabditis elegans ]

    Gene ID: 175677, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tmem-131
    Official Full Name
    Transmembrane protein 131 homolog
    Primary source
    WormBase:WBGene00016170
    Locus tag
    CELE_C27F2.8
    See related
    AllianceGenome:WB:WBGene00016170
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Located in endoplasmic reticulum membrane. Is expressed in hypodermis; intestine; and neurons. Orthologous to human TMEM131 (transmembrane protein 131). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tmem-131 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (4991439..4998161, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene putative F-box protein C27F2.7 Neighboring gene PCI domain-containing protein 2 homolog Neighboring gene WD Repeat protein Neighboring gene Guanine nucleotide exchange protein smcr-8 Neighboring gene Coiled-coil domain-containing protein 25 Neighboring gene Transmembrane protein 144 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Broadly conserved roles of TMEM131 family proteins in intracellular collagen assembly and secretory cargo trafficking. Zhang Z, et al. Sci Adv, 2020 Feb. PMID 32095531, Free PMC Article
    2. The conserved transmembrane protein TMEM-39 coordinates with COPII to promote collagen secretion and regulate ER stress response. Zhang Z, et al. PLoS Genet, 2021 Feb. PMID 33524011, Free PMC Article
    3. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    4. A protein domain-based interactome network for C. elegans early embryogenesis. Boxem M, et al. Cell, 2008 Aug 8. PMID 18692475, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 131 homolog
    NP_498059.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4991439..4998161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065658.8 → NP_498059.2  Transmembrane protein 131 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498059.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G4S3K6, Q18264
      Conserved Domains (4) summary
      pfam04747
      Location:1368 → 1528
      DUF612; Protein of unknown function, DUF612
      pfam05109
      Location:1390 → 1818
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam09507
      Location:1220 → 1485
      CDC27; DNA polymerase subunit Cdc27
      pfam12371
      Location:117 → 199
      TMEM131_like; Transmembrane protein 131-like
    Nucleotide Protein
    Heading Accession and Version

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