Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hnrnpa1provided by RGD
Official Full Name: heterogeneous nuclear ribonucleoprotein A1provided by RGD
Primary source: RGD:69234
See related: EnsemblRapid:ENSRNOG00000036839 AllianceGenome:RGD:69234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Hnrpa1; hnRNP A1
Summary: Enables nucleic acid binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to thapsigargin; and cellular response to tunicamycin. Located in cytosol and nucleoplasmic periphery of the nuclear pore complex. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 20; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3; and tropical spastic paraparesis. Orthologous to several human genes including HNRNPA1L2 (heterogeneous nuclear ribonucleoprotein A1 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 954.1), Spleen (RPKM 755.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (136253633..136260085)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (134375318..134381610)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (144865302..144871592)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
Title: Increase in hnRNPA1 Expression Suffices to Kill Motor Neurons in Transgenic Rats.
Data indicate that heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) participates in the IRES (internal ribosome entry site) -dependent translation of sterol-regulatory-element-binding protein 1 (SREBP-1a) mRNA through RNA-protein interaction.
Title: hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress.
data show that hnRNP A1 is an important Quaking target that contributes to its control of myelin gene expression
Title: Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hnrpa1 (e-PCR), detects polymorphism
- UniSTS:479118

PMC137566P1 (e-PCR)
- UniSTS:270842

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA/DNA annealing activity	IDA Inferred from Direct Assay more info	PubMed
enables G-rich strand telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	TAS Traceable Author Statement more info	PubMed
enables RNA strand annealing activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables miRNA binding	ISO Inferred from Sequence Orthology more info
enables miRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables single-stranded DNA binding	TAS Traceable Author Statement more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables telomeric repeat-containing RNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in RNA metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within RNA splicing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to potassium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to sodium arsenite	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sodium arsenite	ISS Inferred from Sequence or Structural Similarity more info
involved_in import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in nuclear export	ISO Inferred from Sequence Orthology more info
involved_in nuclear export	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasmic periphery of the nuclear pore complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spliceosomal complex	ISO Inferred from Sequence Orthology more info
part_of spliceosomal complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein A1

Names: HDP; helix-destabilizing protein; hnRNP core protein A1; single-strand RNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399274.1 → NP_001386203.1 heterogeneous nuclear ribonucleoprotein A1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P04256

UniProtKB/TrEMBL

A0A8I6ALC1, A6KD00

Related

ENSRNOP00000074880.3, ENSRNOT00000091596.3

Conserved Domains (3) summary

pfam11627
Location:308 → 345

HnRNPA1; Nuclear factor hnRNPA1

cd12582
Location:105 → 184

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

cd12761
Location:12 → 92

RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins
NM_017248.3 → NP_058944.2 heterogeneous nuclear ribonucleoprotein A1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

P04256

UniProtKB/TrEMBL

F7FEZ6, Q5I0M7

Related

ENSRNOP00000052160.6, ENSRNOT00000055285.6

Conserved Domains (3) summary

pfam11627
Location:255 → 292

HnRNPA1; Nuclear factor hnRNPA1

cd12582
Location:105 → 184

RRM2_hnRNPA3; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein A3 (hnRNP A3) and similar proteins

cd12761
Location:12 → 92

RRM1_hnRNPA1; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

136253633..136260085

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263120.1 → XP_063119190.1 heterogeneous nuclear ribonucleoprotein A1 isoform X1

UniProtKB/Swiss-Prot

P04256

UniProtKB/TrEMBL

A0A8I6ALC1, A6KD00
XM_063263121.1 → XP_063119191.1 heterogeneous nuclear ribonucleoprotein A1 isoform X2

UniProtKB/Swiss-Prot

P04256

UniProtKB/TrEMBL

F7FEZ6, Q5I0M7

Related

ENSRNOP00000094714.2, ENSRNOT00000113929.2