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    Klhl8 kelch-like family member 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 289457, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Klhl8provided by RGD
    Official Full Name
    kelch-like family member 8provided by RGD
    Primary source
    RGD:1304685
    See related
    EnsemblRapid:ENSRNOG00000002214 AllianceGenome:RGD:1304685
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in nucleoplasm. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KLHL8 (kelch like family member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 134.7), Muscle (RPKM 103.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl8 in Genome Data Viewer
    Location:
    14p22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (6112472..6158001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5807795..5853325)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (7169517..7215025)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 9 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 11 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 13 Neighboring gene uncharacterized LOC120096561 Neighboring gene ALF transcription elongation factor 1 Neighboring gene similar to human chromosome 4 open reading frame 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Control of rapsyn stability by the CUL-3-containing E3 ligase complex. Nam S, et al. J Biol Chem, 2009 Mar 20. PMID 19158078, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 8
    Names
    kelch-like 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105995.1 → NP_001099465.1  kelch-like protein 8

      See identical proteins and their annotated locations for NP_001099465.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474022
      UniProtKB/TrEMBL
      A0A0G2JYB7, A6K5U5
      Conserved Domains (5) summary
      smart00612
      Location:509 → 555
      Kelch; Kelch domain
      PHA03098
      Location:61 → 536
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:357 → 400
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:58 → 162
      BTB; BTB/POZ domain
      pfam07707
      Location:170 → 272
      BACK; BTB And C-terminal Kelch

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      6112472..6158001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008770006.4 → XP_008768228.1  kelch-like protein 8 isoform X1

      See identical proteins and their annotated locations for XP_008768228.1

      UniProtKB/TrEMBL
      A0A0G2JYB7, A6K5U5
      Related
      ENSRNOP00000070593.2, ENSRNOT00000081600.3
      Conserved Domains (5) summary
      smart00612
      Location:509 → 555
      Kelch; Kelch domain
      PHA03098
      Location:61 → 536
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:357 → 400
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:58 → 162
      BTB; BTB/POZ domain
      pfam07707
      Location:170 → 272
      BACK; BTB And C-terminal Kelch

    2. XM_008770005.4 → XP_008768227.1  kelch-like protein 8 isoform X1

      See identical proteins and their annotated locations for XP_008768227.1

      UniProtKB/TrEMBL
      A0A0G2JYB7, A6K5U5
      Conserved Domains (5) summary
      smart00612
      Location:509 → 555
      Kelch; Kelch domain
      PHA03098
      Location:61 → 536
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:357 → 400
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:58 → 162
      BTB; BTB/POZ domain
      pfam07707
      Location:170 → 272
      BACK; BTB And C-terminal Kelch

    3. XM_008770004.4 → XP_008768226.1  kelch-like protein 8 isoform X1

      See identical proteins and their annotated locations for XP_008768226.1

      UniProtKB/TrEMBL
      A0A0G2JYB7, A6K5U5
      Related
      ENSRNOP00000111584.1, ENSRNOT00000159280.1
      Conserved Domains (5) summary
      smart00612
      Location:509 → 555
      Kelch; Kelch domain
      PHA03098
      Location:61 → 536
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:357 → 400
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:58 → 162
      BTB; BTB/POZ domain
      pfam07707
      Location:170 → 272
      BACK; BTB And C-terminal Kelch

    4. XM_063272896.1 → XP_063128966.1  kelch-like protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYB7, A6K5U5

    5. XM_063272895.1 → XP_063128965.1  kelch-like protein 8 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYB7, A6K5U5
    Nucleotide Protein Strain
    Heading Accession and Version

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