Igf2r insulin-like growth factor 2 receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igf2rprovided by RGD
Official Full Name: insulin-like growth factor 2 receptorprovided by RGD
Primary source: RGD:2871
See related: EnsemblRapid:ENSRNOG00000014997 AllianceGenome:RGD:2871
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Igfr2; IGF-IIR
Summary: Enables several functions, including G-protein alpha-subunit binding activity; insulin-like growth factor II binding activity; and retinoic acid binding activity. Involved in several processes, including animal organ regeneration; response to retinoic acid; and response to tetrachloromethane. Located in several cellular components, including late endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of clathrin coat. Used to study lung adenocarcinoma. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 538.7), Heart (RPKM 422.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (50526878..50615265)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (47979109..48067501)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (48176095..48264482)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cardiac-specific overexpression of insulin-like growth factor II receptor-alpha interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions.
Title: Cardiac-specific overexpression of insulin-like growth factor II receptor-α interferes with the regulation of calcium homeostasis in the heart under hyperglycemic conditions.
Insulin-like growth factor II receptor alpha overexpression in heart aggravates hyperglycemia-induced cardiac inflammation and myocardial necrosis.
Title: Insulin-like growth factor II receptor alpha overexpression in heart aggravates hyperglycemia-induced cardiac inflammation and myocardial necrosis.
Expression of IGF-2 Receptor in the Auditory Cortex Improves the Precision of Recent Fear Memories and Maintains Detailed Remote Fear Memories Over Time.
Title: Expression of IGF-2 Receptor in the Auditory Cortex Improves the Precision of Recent Fear Memories and Maintains Detailed Remote Fear Memories Over Time.
Perturbed ER homeostasis by IGF-IIRalpha promotes cardiac damage under stresses.
Title: Perturbed ER homeostasis by IGF-IIRα promotes cardiac damage under stresses.
The combined inhibition of the CaMKIIdelta and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
Title: The combined inhibition of the CaMKIIδ and calcineurin signaling cascade attenuates IGF-IIR-induced cardiac hypertrophy.
Finding provide evidence that IGF-IIRalpha plays a crucial role in enhancing cardiac hypertrophy under high-salt conditions.
Title: Synergistic cardiac pathological hypertrophy induced by high-salt diet in IGF-IIRα cardiac-specific transgenic rats.
IGF-IIR predominantly induces mitophagy through the Rab9-dependent alternative autophagy.
Title: Rab9-dependent autophagy is required for the IGF-IIR triggering mitophagy to eliminate damaged mitochondria.
elevated glucose-induced IGF2R expression leads to enhanced IGF2R signaling cascade, which further leads to greater activation of downstream cardiac hypertrophy and apoptosis-associated effector protein molecules resulting in increased apoptosis of cardiomyocytes
Title: Cardiac apoptosis induced under high glucose condition involves activation of IGF2R signaling in H9c2 cardiomyoblasts and streptozotocin-induced diabetic rat hearts.
p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure
Title: p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure.
We aimed to investigate whether TSN protected H9c2 cardiomyocytes from AngII-induced activation of IGF-2R pathway (IGF-2 and IGF-2R )and hypertrophy by mediating through Estrogen receptors
Title: Tanshinone-induced ERs suppresses IGFII activation to alleviate Ang II-mediated cardiac hypertrophy.

Submit: New GeneRIF Correction See all GeneRIFs (28)

General gene information

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Markers

25.mHAa3f1.seq (e-PCR)
- UniSTS:123708

RH94626 (e-PCR)
- UniSTS:119874

RH137924 (e-PCR)
- UniSTS:220011

Igf2r (e-PCR), detects polymorphism
- UniSTS:143483

RH128065 (e-PCR)
- UniSTS:211373

Igf2r (e-PCR), detects polymorphism
- UniSTS:516549

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-mannose binding	ISO Inferred from Sequence Orthology more info
enables G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor II binding	IDA Inferred from Direct Assay more info	PubMed
enables insulin-like growth factor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin-like growth factor binding	ISO Inferred from Sequence Orthology more info
enables insulin-like growth factor receptor activity	TAS Traceable Author Statement more info	PubMed
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables retromer complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in liver development	IDA Inferred from Direct Assay more info	PubMed
involved_in lysosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation by host of viral process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to retinoic acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to tetrachloromethane	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
part_of clathrin coat	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cation-independent mannose-6-phosphate receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012756.2 → NP_036888.2 cation-independent mannose-6-phosphate receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6KJW4, G3V824, Q63002, Q63757

Related

ENSRNOP00000021840.3, ENSRNOT00000021840.6

Conserved Domains (3) summary

smart00059
Location:1888 → 1933

FN2; Fibronectin type 2 domain

pfam00878
Location:1022 → 1169

CIMR; Cation-independent mannose-6-phosphate receptor repeat

pfam02157
Location:1202 → 1354

Man-6-P_recep; Mannose-6-phosphate receptor