U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zbtb46 zinc finger and BTB domain containing 46 [ Mus musculus (house mouse) ]

    Gene ID: 72147, updated on 5-Nov-2024

    Summary

    Official Symbol
    Zbtb46provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 46provided by MGI
    Primary source
    MGI:MGI:1919397
    See related
    Ensembl:ENSMUSG00000027583 AllianceGenome:MGI:1919397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BZEL; Btbd4; 2610019F01Rik; 4933406L05Rik
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of leukocyte activation and regulation of leukocyte differentiation. Located in chromatin. Is expressed in several structures, including brown fat; central nervous system; gonad; renal vasculature; and spleen. Orthologous to human ZBTB46 (zinc finger and BTB domain containing 46). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.1), lung adult (RPKM 4.0) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zbtb46 in Genome Data Viewer
    Location:
    2 H4; 2 103.63 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181012105..181134776, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181371009..181493262, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10172 Neighboring gene STARR-seq mESC enhancer starr_06749 Neighboring gene STARR-seq mESC enhancer starr_06750 Neighboring gene STARR-seq mESC enhancer starr_06751 Neighboring gene regulator of telomere elongation helicase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4532 Neighboring gene ADP-ribosylation factor related protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E11178 Neighboring gene zinc finger, CCCH-type with G patch domain Neighboring gene Slc2a4 regulator, pseudogene Neighboring gene Lck interacting transmembrane adaptor 1 Neighboring gene predicted gene, 22708 Neighboring gene STARR-positive B cell enhancer mm9_chr2:181218272-181218572 Neighboring gene STARR-seq mESC enhancer starr_06754 Neighboring gene STARR-positive B cell enhancer ABC_E274 Neighboring gene abhydrolase domain containing 16B Neighboring gene tumor protein D52-like 2 Neighboring gene predicted gene, 25184

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (9)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of granulocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of leukocyte activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of monocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of plasmacytoid dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 46
    Names
    BTB (POZ) domain containing 4
    BTB-ZF protein expressed in effector lymphocytes
    BTB/POZ domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027656.3NP_081932.1  zinc finger and BTB domain-containing protein 46 isoform 1

      See identical proteins and their annotated locations for NP_081932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL928965, AL929094
      Consensus CDS
      CCDS50854.1
      UniProtKB/Swiss-Prot
      A2AUD2, Q3U2R2, Q8BID6, Q9D0G6, Q9D492
      Related
      ENSMUSP00000137014.2, ENSMUST00000180222.8
      Conserved Domains (4) summary
      sd00017
      Location:420440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18230
      Location:10134
      BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
      pfam13465
      Location:433457
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:418442
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. NM_028125.3NP_082401.1  zinc finger and BTB domain-containing protein 46 isoform 2

      See identical proteins and their annotated locations for NP_082401.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 3' terminus, compared to variant 1, that results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK011461, AL929094
      Consensus CDS
      CCDS17212.1
      UniProtKB/Swiss-Prot
      Q8BID6
      Related
      ENSMUSP00000084672.4, ENSMUST00000087409.10
      Conserved Domains (1) summary
      cd18230
      Location:10134
      BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181012105..181134776 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500714.5XP_006500777.1  zinc finger and BTB domain-containing protein 46 isoform X2

      Conserved Domains (4) summary
      sd00017
      Location:420440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18230
      Location:10134
      BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
      pfam13465
      Location:433457
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:418442
      zf-H2C2_5; C2H2-type zinc-finger domain
    2. XM_006500713.4XP_006500776.1  zinc finger and BTB domain-containing protein 46 isoform X1

      See identical proteins and their annotated locations for XP_006500776.1

      UniProtKB/Swiss-Prot
      A2AUD2, Q3U2R2, Q8BID6, Q9D0G6, Q9D492
      Conserved Domains (4) summary
      sd00017
      Location:420440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18230
      Location:10134
      BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
      pfam13465
      Location:433457
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:418442
      zf-H2C2_5; C2H2-type zinc-finger domain
    3. XM_006500712.5XP_006500775.1  zinc finger and BTB domain-containing protein 46 isoform X1

      UniProtKB/Swiss-Prot
      A2AUD2, Q3U2R2, Q8BID6, Q9D0G6, Q9D492
      Related
      ENSMUSP00000029106.7, ENSMUST00000029106.13
      Conserved Domains (4) summary
      sd00017
      Location:420440
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18230
      Location:10134
      BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)
      pfam13465
      Location:433457
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:418442
      zf-H2C2_5; C2H2-type zinc-finger domain
    4. XM_006500715.5XP_006500778.1  zinc finger and BTB domain-containing protein 46 isoform X3

      Conserved Domains (1) summary
      cd18230
      Location:10134
      BTB_POZ_ZBTB46; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46)

    RNA

    1. XR_867136.4 RNA Sequence

    2. XR_001783183.3 RNA Sequence

    3. XR_375402.5 RNA Sequence