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    FBXO15 F-box protein 15 [ Homo sapiens (human) ]

    Gene ID: 201456, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FBXO15provided by HGNC
    Official Full Name
    F-box protein 15provided by HGNC
    Primary source
    HGNC:HGNC:13617
    See related
    Ensembl:ENSG00000141665 MIM:609093; AllianceGenome:HGNC:13617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBX15
    Summary
    Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 2.7), kidney (RPKM 0.4) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBXO15 in Genome Data Viewer
    Location:
    18q22.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (74073368..74147834, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (74294328..74368800, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (71740603..71815069, complement)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372191 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:71510186-71510359 Neighboring gene uncharacterized LOC124904358 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50059 Neighboring gene Sharpr-MPRA regulatory region 9472 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13493 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:71817752-71818951 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:71822138-71823337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13494 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_50247 Neighboring gene translocase of inner mitochondrial membrane 21 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:71864836-71865492 Neighboring gene RNA, 7SL, cytoplasmic 551, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression. Zhao Y, et al. Signal Transduct Target Ther, 2021 Jun 4. PMID 34083507, Free PMC Article
    2. FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells. Katayama K, et al. Cancer Sci, 2013 Jun. PMID 23465077, Free PMC Article
    3. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Chen BB, et al. Cell Rep, 2014 Apr 24. PMID 24703837, Free PMC Article
    4. Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Tokuzawa Y, et al. Mol Cell Biol, 2003 Apr. PMID 12665572, Free PMC Article
    5. Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs. Clijsters L, et al. Mol Cell, 2019 Jun 20. PMID 31130363, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression.
      Title: FBXO15 plays a critical suppressive functional role in regulation of breast cancer progression.
    2. These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.
      Title: FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin--proteasome pathway in cancer cells.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study of sleep habits and insomnia.
    EBI GWAS Catalog
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    EBI GWAS Catalog
    A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
    EBI GWAS Catalog
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    EBI GWAS Catalog
    Genetics of coronary artery calcification among African Americans, a meta-analysis.
    EBI GWAS Catalog
    Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC39671

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142958.2 → NP_001136430.1  F-box only protein 15 isoform 2

      See identical proteins and their annotated locations for NP_001136430.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an upstream start codon, compared to variant 1. The resulting protein (isoform 2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK094215, BU729305, DB447209
      Consensus CDS
      CCDS45884.1
      UniProtKB/Swiss-Prot
      B3KST3, Q8NCQ5
      Related
      ENSP00000393154.2, ENST00000419743.7
      Conserved Domains (1) summary
      pfam12937
      Location:74 → 118
      F-box-like; F-box-like

    2. NM_152676.3 → NP_689889.1  F-box only protein 15 isoform 1

      See identical proteins and their annotated locations for NP_689889.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter protein (isoform 1).
      Source sequence(s)
      AC084702, BC029579, BI829755, BU729305
      Conserved Domains (1) summary
      pfam12937
      Location:2 → 42
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      74073368..74147834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525856.2 → XP_011524158.1  F-box only protein 15 isoform X1

      Conserved Domains (1) summary
      pfam12937
      Location:74 → 118
      F-box-like; F-box-like

    2. XM_047437341.1 → XP_047293297.1  F-box only protein 15 isoform X3

    3. XM_047437342.1 → XP_047293298.1  F-box only protein 15 isoform X3

    4. XM_017025604.3 → XP_016881093.1  F-box only protein 15 isoform X3

      Conserved Domains (1) summary
      pfam12937
      Location:2 → 42
      F-box-like; F-box-like

    5. XM_011525860.1 → XP_011524162.1  F-box only protein 15 isoform X6

      Conserved Domains (1) summary
      pfam12937
      Location:74 → 118
      F-box-like; F-box-like

    6. XM_024451099.2 → XP_024306867.1  F-box only protein 15 isoform X2

      Conserved Domains (1) summary
      pfam12937
      Location:74 → 118
      F-box-like

    7. XM_047437343.1 → XP_047293299.1  F-box only protein 15 isoform X5

    8. XM_011525858.2 → XP_011524160.1  F-box only protein 15 isoform X4

      Conserved Domains (1) summary
      pfam12937
      Location:74 → 118
      F-box-like; F-box-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      74294328..74368800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318265.1 → XP_054174240.1  F-box only protein 15 isoform X1

    2. XM_054318268.1 → XP_054174243.1  F-box only protein 15 isoform X3

    3. XM_054318269.1 → XP_054174244.1  F-box only protein 15 isoform X3

    4. XM_054318267.1 → XP_054174242.1  F-box only protein 15 isoform X3

    5. XM_054318272.1 → XP_054174247.1  F-box only protein 15 isoform X6

    6. XM_054318266.1 → XP_054174241.1  F-box only protein 15 isoform X2

    7. XM_054318271.1 → XP_054174246.1  F-box only protein 15 isoform X5

    8. XM_054318270.1 → XP_054174245.1  F-box only protein 15 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NCQ5.2 GenPept UniProtKB/Swiss-Prot:Q8NCQ5

    Gene LinkOut

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