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    SFT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853863, updated on 22-Aug-2024

    Summary

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    Official Symbol
    SFT1
    Primary source
    FungiDB:YKL006C-A
    Locus tag
    YKL006C-A
    See related
    SGD:S000002101; AllianceGenome:SGD:S000002101; VEuPathDB:YKL006C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables SNAP receptor activity. Involved in intra-Golgi vesicle-mediated transport and vesicle fusion. Located in Golgi trans cisterna. Part of SNARE complex. Human ortholog(s) of this gene implicated in uterine fibroid. Orthologous to human BET1L (Bet1 golgi vesicular membrane trafficking protein like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XI
    Exon count:
    2
    Sequence:
    Chromosome: XI; NC_001143.9 (430198..430632, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene sphingosine N-acyltransferase LAC1 Neighboring gene Cap1p Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L14A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Short transmembrane domains with high-volume exoplasmic halves determine retention of Type II membrane proteins in the Golgi complex. Quiroga R, et al. J Cell Sci, 2013 Dec 1. PMID 24105265
    2. Ykt6p is a multifunctional yeast R-SNARE that is required for multiple membrane transport pathways to the vacuole. Kweon Y, et al. Mol Biol Cell, 2003 May. PMID 12802061, Free PMC Article
    3. A SNARE-like protein required for traffic through the Golgi complex. Banfield DK, et al. Nature, 1995 Jun 29. PMID 7596416
    4. AtBS14a and AtBS14b, two Bet1/Sft1-like SNAREs from Arabidopsis thaliana that complement mutations in the yeast SFT1 gene. Tai WC, et al. FEBS Lett, 2001 Jul 6. PMID 11445081
    5. Multiple features within the syntaxin Sed5p mediate its Golgi localization. Gao G, et al. Traffic, 2020 Mar. PMID 31883188

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sft1p
    NP_012919.3
    • Intra-Golgi v-SNARE; required for transport of proteins between an early and a later Golgi compartment

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      430198..430632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180028.3 → NP_012919.3  TPA: Sft1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012919.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXT0, P43682
      UniProtKB/TrEMBL
      A6ZZV9, B3LR78, C7GRG5, C8ZCG0, G2WI25, N1P0T5
      Conserved Domains (1) summary
      cd15853
      Location:10 → 68
      SNARE_Bet1; SNARE motif of Bet1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43682.1

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