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    QCR8 ubiquinol--cytochrome-c reductase subunit 8 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853273, updated on 17-May-2024

    Summary

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    Gene symbol
    QCR8
    Gene description
    ubiquinol--cytochrome-c reductase subunit 8
    Primary source
    FungiDB:YJL166W
    Locus tag
    YJL166W
    See related
    SGD:S000003702; AllianceGenome:SGD:S000003702; VEuPathDB:YJL166W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COR5
    Summary
    Enables ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 4. Orthologous to human UQCRQ (ubiquinol-cytochrome c reductase complex III subunit VII). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See QCR8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (106434..106718)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene histone methyltransferase SET2 Neighboring gene bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase Neighboring gene protein kinase HAL5 Neighboring gene cAMP-dependent protein kinase catalytic subunit TPK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquinone accumulates in the mitochondria of yeast mutated in the ubiquinone binding protein, Qcr8p. Hagerman RA, et al. Biochem Biophys Res Commun, 2006 May 26. PMID 16597436
    2. Metabolic control analysis of the bc1 complex of Saccharomyces cerevisiae: effect on cytochrome c oxidase, respiration and growth rate. Boumans H, et al. Biochem J, 1998 May 1. PMID 9560317, Free PMC Article
    3. Subunit 8 of the Saccharomyces cerevisiae cytochrome bc1 complex interacts with succinate-ubiquinone reductase complex. Bruel C, et al. J Bioenerg Biomembr, 1996 Feb. PMID 8786239
    4. Distinct transcriptional regulation of a gene coding for a mitochondrial protein in the yeasts Saccharomyces cerevisiae and Kluyveromyces lactis despite similar promoter structures. Mulder W, et al. Mol Microbiol, 1995 Sep. PMID 8596431
    5. A region of the C-terminal part of the 11-kDa subunit of ubiquinol-cytochrome-c oxidoreductase of the yeast Saccharomyces cerevisiae contributes to the structure of the Qout reaction domain. Hemrika W, et al. Eur J Biochem, 1993 Aug 1. PMID 8394810

    See all (95) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ubiquinol-cytochrome-c reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial electron transport, ubiquinol to cytochrome c IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial respiratory chain complex III IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquinol--cytochrome-c reductase subunit 8
    NP_012369.1
    • Subunit 8 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      106434..106718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181599.1 → NP_012369.1  TPA: ubiquinol--cytochrome-c reductase subunit 8 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012369.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW21, P08525
      UniProtKB/TrEMBL
      A0A6A5PU80, A6ZQG6, B3LPV7, C7GRZ4, C8ZB53, G2WGK7, N1P3U7
      Conserved Domains (1) summary
      pfam02939
      Location:12 → 89
      UcrQ; UcrQ family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6T0B_H.1
    6T0B_S.1
    6T15_H.1
    6T15_S.1
    P08525.2

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