HAL5 protein kinase HAL5 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: HAL5
Gene description: protein kinase HAL5
Primary source: FungiDB:YJL165C
Locus tag: YJL165C
See related: SGD:S000003701; AllianceGenome:SGD:S000003701; VEuPathDB:YJL165C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein kinase activity. Involved in several processes, including detection of nutrient; positive regulation of endocytosis; and protein dephosphorylation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

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Authors demonstrate that loss of Hal4 and Hal5 activates endocytosis of many different kinds of PM proteins, including Art1-mediated and Art1-independent endocytic events.
Title: A Snf1-related nutrient-responsive kinase antagonizes endocytosis in yeast.
Caffeine sensitivity of the Deltappz1 disruptant is suppressed by disruption of either SAT4 or HAL5.
Title: Saccharomyces cerevisiae protein phosphatase Ppz1 and protein kinases Sat4 and Hal5 are involved in the control of subcellular localization of Gln3 by likely regulating its phosphorylation state.
Hal4 and Hal5 are required for control of carbon and nitrogen uptake and metabolism.
Title: Hal4 and Hal5 protein kinases are required for general control of carbon and nitrogen uptake and metabolism.
The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in
Title: The protein kinase Hal5p is the high-copy suppressor of lithium-sensitive mutations of genes involved in the sporulation and meiosis as well as the ergosterol biosynthesis in Saccharomyces cerevisiae.
Sat4/Hal4 and Hal5 stabilize the transporter at the plasma membrane under low K+ conditions, preventing its endocytosis and vacuolar degradation.
Title: Key role for intracellular K+ and protein kinases Sat4/Hal4 and Hal5 in the plasma membrane stabilization of yeast nutrient transporters.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	HDA more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular monoatomic cation homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular monoatomic cation homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

NP_012370.1

Snf1p-related nutrient-responsive protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication

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