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    COX6 cytochrome c oxidase subunit VI [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856448, updated on 29-Jun-2024

    Summary

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    Gene symbol
    COX6
    Gene description
    cytochrome c oxidase subunit VI
    Primary source
    FungiDB:YHR051W
    Locus tag
    YHR051W
    See related
    SGD:S000001093; AllianceGenome:SGD:S000001093; VEuPathDB:YHR051W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of mitochondrial respiratory chain complex IV. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX5A (cytochrome c oxidase subunit 5A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COX6 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (209705..210151)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene divalent metal ion transporter SMF2 Neighboring gene uncharacterized protein Neighboring gene Cic1p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene metallothionein CUP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. pH and the cAMP-dependent protein kinase mediate growth phase induction of the cytochrome c oxidase subunit VI gene, COX6, in Saccharomyces cerevisiae. Wright RM, et al. Biochem Biophys Res Commun, 1995 Sep 25. PMID 7575509
    2. Identification of an upstream activation sequence and other cis-acting elements required for transcription of COX6 from Saccharomyces cerevisiae. Trawick JD, et al. Mol Cell Biol, 1989 Dec. PMID 2555697, Free PMC Article
    3. Multiple pathways of mitochondrial-nuclear communication in yeast: intergenomic signaling involves ABF1 and affects a different set of genes than retrograde regulation. Woo DK, et al. Biochim Biophys Acta, 2009 Feb. PMID 18977319
    4. A role for Pet100p in the assembly of yeast cytochrome c oxidase: interaction with a subassembly that accumulates in a pet100 mutant. Church C, et al. J Biol Chem, 2005 Jan 21. PMID 15507444
    5. Oxygen regulation of the cytochrome c oxidase subunit VI gene, COX6, in Saccharomyces cerevisiae. Wright RM, et al. Biochem Biophys Res Commun, 1995 Nov 13. PMID 7488164

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase.
      Title: Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase.
    2. Atco, a yeast mitochondrial complex of Atp9 and Cox6, is an assembly intermediate of the ATP synthase.
      Title: Atco, a yeast mitochondrial complex of Atp9 and Cox6, is an assembly intermediate of the ATP synthase.
    3. rotor component assembly of yeast mitochondrial ATP synthase is enhanced when Atp9p is supplied by Atp9p-Cox6p complexes
      Title: Assembly of the rotor component of yeast mitochondrial ATP synthase is enhanced when Atp9p is supplied by Atp9p-Cox6p complexes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cytochrome-c oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, cytochrome c to oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, cytochrome c to oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex IV IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit VI
    NP_011918.1
    • Subunit VI of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      209705..210151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179181.1 → NP_011918.1  TPA: cytochrome c oxidase subunit VI [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL00, P00427
      UniProtKB/TrEMBL
      A0A6A5PUE0, A6ZSV9, B3LSH0, C7GT91, C8ZAC2, G2WFC5, N1P1M2
      Conserved Domains (1) summary
      pfam02284
      Location:49 → 145
      COX5A; Cytochrome c oxidase subunit Va
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00427.1

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