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    KEL2 Kel2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853153, updated on 17-May-2024

    Summary

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    Gene symbol
    KEL2
    Gene description
    Kel2p
    Primary source
    FungiDB:YGR238C
    Locus tag
    YGR238C
    See related
    SGD:S000003470; AllianceGenome:SGD:S000003470; VEuPathDB:YGR238C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in several processes, including conjugation with cellular fusion; regulation of cell cycle process; and regulation of formin-nucleated actin cable assembly. Located in cellular bud neck; cellular bud tip; and mating projection tip. Part of Kelch-containing formin regulatory complex. Orthologous to human RABEPK (Rab9 effector protein with kelch motifs) and KLHDC3 (kelch domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KEL2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (966039..968687, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Spg1p Neighboring gene uncharacterized protein Neighboring gene Pex21p Neighboring gene 6-phosphofructokinase subunit alpha

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The protein kinase C-mediated MAP kinase pathway involved in the maintenance of cellular integrity in Saccharomyces cerevisiae. Heinisch JJ, et al. Mol Microbiol, 1999 May. PMID 10361272
    2. Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis. Gould CJ, et al. J Biol Chem, 2014 Jun 27. PMID 24828508, Free PMC Article
    3. The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast. Knaus M, et al. EMBO J, 2005 Sep 7. PMID 16107882, Free PMC Article
    4. Kel1p Mediates Yeast Cell Fusion Through a Fus2p- and Cdc42p-Dependent Mechanism. Smith JA, et al. Genetics, 2016 Apr. PMID 26865368, Free PMC Article
    5. Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. Philips J, et al. J Cell Biol, 1998 Oct 19. PMID 9786949, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bud14, Kel1, and Kel2 interact to form a stable 520-kDa complex that controls actin cable assembly and cell morphogenesis.
      Title: Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of bipolar cell polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of formin-nucleated actin cable assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Kelch-containing formin regulatory complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell cortex of cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kel2p
    NP_011754.3
    • Protein that negatively regulates mitotic exit; forms a complex with Kel1p and Bud14p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel1p, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      966039..968687 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181367.3 → NP_011754.3  TPA: Kel2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011754.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV18, P50090
      UniProtKB/TrEMBL
      A0A8H8UKX1, A6ZUP6, B3LI02, C7GNJ1
      Conserved Domains (4) summary
      PLN02153
      Location:139 → 379
      PLN02153; epithiospecifier protein
      COG1196
      Location:603 → 882
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      sd00038
      Location:257 → 308
      Kelch; KELCH repeat [structural motif]
      pfam13854
      Location:82 → 116
      Kelch_5; Kelch motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50090.1

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