GPP2 glycerol-1-phosphatase HOR2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GPP2
Official Full Name: glycerol-1-phosphatase HOR2
Primary source: SGD:S000000864
Locus tag: YER062C
See related: AllianceGenome:SGD:S000000864; FungiDB:YER062C; VEuPathDB:YER062C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HOR2
Summary: Enables glycerol-1-phosphatase activity. Involved in glycerol biosynthetic process and response to osmotic stress. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See GPP2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (279930..280682, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

osmotic up-regulation of only two Hog1-dependent glycerol biosynthesis genes, GPD1 and GPP2, is sufficient for successful osmoadaptation.
Title: Rewiring yeast osmostress signalling through the MAPK network reveals essential and non-essential roles of Hog1 in osmoadaptation.
Study found that the gpp1gpp2 strain is hypersensitive to cell wall stress such as treatment with beta-1,3-glucanase containing cocktail Zymolyase and chitin-binding dye Calcofluor-white.
Title: Thermosensitivity of the Saccharomyces cerevisiae gpp1gpp2 double deletion strain can be reduced by overexpression of genes involved in cell wall maintenance.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables beta-phosphoglucomutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycerol-1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glycerol-1-phosphatase HOR2

NP_010984.3

EC 3.1.3.21

DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis; also known as glycerol-1-phosphatase; induced in response to hyperosmotic or oxidative stress, and during diauxic shift; GPP2 has a paralog, GPP1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

279930..280682 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178953.3 → NP_010984.3 TPA: glycerol-1-phosphatase HOR2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010984.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLW7, P40106

UniProtKB/TrEMBL

A6ZR16, B3LS76, B5VHJ4, C7GTD0, C8Z768, G2WCV1, N1P561

Conserved Domains (1) summary

cd07527
Location:14 → 227

HAD_ScGPP-like; subfamily of beta-phosphoglucomutase-like family, similar to Saccharomyces cerevisiae DL-glycerol-3-phosphate phosphatase (GPP1p/ Rhr2p and GPP2p/HOR2p) and 2-deoxyglucose-6-phosphate phosphatase (DOG1p and DOG2p)