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    THO1 Tho1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856792, updated on 29-Jun-2024

    Summary

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    Gene symbol
    THO1
    Gene description
    Tho1p
    Primary source
    FungiDB:YER063W
    Locus tag
    YER063W
    See related
    SGD:S000000865; AllianceGenome:SGD:S000000865; VEuPathDB:YER063W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity; chromatin binding activity; and double-stranded DNA binding activity. Involved in poly(A)+ mRNA export from nucleus; ribonucleoprotein complex assembly; and transcription elongation from RNA polymerase II promoter. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See THO1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (281710..282366)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene fatty acid synthase CEM1 Neighboring gene glycerol-1-phosphatase HOR2 Neighboring gene Vhr2p Neighboring gene isocitrate lyase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-resolution NMR structures of the domains of Saccharomyces cerevisiae Tho1. Jacobsen JO, et al. Acta Crystallogr F Struct Biol Commun, 2016 Jun. PMID 27303905, Free PMC Article
    2. Engineering a two-helix bundle protein for folding studies. Dodson CA, et al. Protein Eng Des Sel, 2010 May. PMID 20130106, Free PMC Article
    3. A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. Piruat JI, et al. EMBO J, 1998 Aug 17. PMID 9707445, Free PMC Article
    4. Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants. Jimeno S, et al. Mol Cell Biol, 2006 Jun. PMID 16738307, Free PMC Article
    5. Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation. Libri D, et al. Mol Cell Biol, 2002 Dec. PMID 12417728, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of Tho1 or Sub2 may provide alternative ways for mRNP formation and export in the absence of a functional THO complex.
      Title: Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein-RNA complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tho1p
    NP_010985.1
    • Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      281710..282366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178954.1 → NP_010985.1  TPA: Tho1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010985.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLW8, P40040
      UniProtKB/TrEMBL
      A0A6A5PX64, A6ZR17, B3LS77, C7GTD1, C8Z769, N1P6Y8
      Conserved Domains (3) summary
      PRK13108
      Location:39 → 109
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      pfam02037
      Location:4 → 38
      SAP; SAP domain
      pfam18592
      Location:127 → 164
      Tho1_MOS11_C; Tho1/MOS11 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40040.1

    Gene LinkOut

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