U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    HIS1 ATP phosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856782, updated on 29-Jun-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    HIS1
    Gene description
    ATP phosphoribosyltransferase
    Primary source
    FungiDB:YER055C
    Locus tag
    YER055C
    See related
    SGD:S000000857; AllianceGenome:SGD:S000000857; VEuPathDB:YER055C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATP phosphoribosyltransferase activity. Involved in histidine biosynthetic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See HIS1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (264892..265785, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Gip2p Neighboring gene purine-cytosine permease Neighboring gene ribosomal 60S subunit protein L34A

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Further evidence of a disparity between conversion and restoration in the his1 locus of Saccharomyces cerevisiae. Hastings PJ, et al. Curr Genet, 1984 Jan. PMID 24177525
    2. Allelic Complementation in the First Gene for Histidine Biosynthesis in SACCHAROMYCES CEREVISIAE. II. Complementation Mapping of Mutants and a Subunit Model of the Enzyme. Korch CT. Genetics, 1973 Jun. PMID 17248619, Free PMC Article
    3. Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae. Hinnebusch AG, et al. J Biol Chem, 1983 Apr 25. PMID 6300123
    4. Novel interallelic complementation at the his1 locus of yeast. Lax C, et al. Genetics, 1978 Nov. PMID 365680, Free PMC Article
    5. Mutagenic and antioxidant activities of Croton lechleri sap in biological systems. Lopes MI, et al. J Ethnopharmacol, 2004 Dec. PMID 15507372

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP phosphoribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ATP phosphoribosyltransferase
    NP_010975.3
    • ATP phosphoribosyltransferase; a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      264892..265785 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178946.3 → NP_010975.3  TPA: ATP phosphoribosyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010975.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLV8, P00498
      UniProtKB/TrEMBL
      A0A8H8ULS1, A6ZR07, C7GX46, C8Z760, G2WCU1, N1P551
      Conserved Domains (1) summary
      COG0040
      Location:9 → 297
      HisG; ATP phosphoribosyltransferase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00498.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools