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    FCY2 purine-cytosine permease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856783, updated on 28-Oct-2024

    Summary

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    Official Symbol
    FCY2
    Official Full Name
    purine-cytosine permease
    Primary source
    SGD:S000000858
    Locus tag
    YER056C
    See related
    AllianceGenome:SGD:S000000858; FungiDB:YER056C; VEuPathDB:YER056C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BRA7
    Summary
    Enables cytidine transmembrane transporter activity and nucleobase transmembrane transporter activity. Involved in cytidine transport; cytosine transport; and purine-containing compound transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See FCY2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (266512..268113, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Gip2p Neighboring gene ATP phosphoribosyltransferase Neighboring gene ribosomal 60S subunit protein L34A Neighboring gene putative isoleucine biosynthesis protein HMF1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fluorocytosine causes uncoupled dissipation of the proton gradient and behaves as an imperfect substrate of the yeast cytosine permease. Hopkins P, et al. Yeast, 1992 Dec. PMID 1293884
    2. In vivo phosphorylation of the purine/cytosine permease from the plasma membrane of the yeast Saccharomyces cerevisiae. Pinson B, et al. Eur J Biochem, 1996 Jul 15. PMID 8706752
    3. Cytosine accumulation as a measure of the proton electrochemical gradient acting on the overexpressed cytosine permease of Saccharomyces cerevisiae. Eddy AA, et al. Microbiology (Reading), 1996 Mar. PMID 8868419
    4. Functional analysis of mutated purine-cytosine permease from Saccharomyces cerevisiae. A possible role of the hydrophilic segment 371-377 in the active carrier conformation. Ferreira T, et al. J Biol Chem, 1997 Apr 11. PMID 9092500
    5. Characterization of the Saccharomyces cerevisiae cytosine transporter using energizable plasma membrane vesicles. Pinson B, et al. J Biol Chem, 1997 Nov 14. PMID 9360962

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytidine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytidine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleobase transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleobase transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytidine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytidine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytosine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytosine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine-containing compound transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    purine-cytosine permease
    NP_010976.1
    • Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      266512..268113 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178947.1 → NP_010976.1  TPA: purine-cytosine permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010976.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLV9, P17064
      UniProtKB/TrEMBL
      C8Z761
      Conserved Domains (1) summary
      COG1457
      Location:65 → 533
      CodB; Purine-cytosine permease or related protein [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17064.2

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