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    SAH1 adenosylhomocysteinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856766, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SAH1
    Official Full Name
    adenosylhomocysteinase
    Primary source
    SGD:S000000845
    Locus tag
    YER043C
    See related
    AllianceGenome:SGD:S000000845; FungiDB:YER043C; VEuPathDB:YER043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables adenosylhomocysteinase activity. Involved in S-adenosylhomocysteine catabolic process; phosphatidylcholine biosynthetic process; and triglyceride metabolic process. Located in cytoplasm. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; hyperhomocysteinemia; and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SAH1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (235770..237119, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene crossover junction endodeoxyribonuclease Neighboring gene peptide-methionine-S-sulfoxide reductase Neighboring gene Erg28p Neighboring gene Mei4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of S-adenosylmethionine in G1 cell-cycle regulation in Saccharomyces cerevisiae. Mizunuma M, et al. Proc Natl Acad Sci U S A, 2004 Apr 20. PMID 15073333, Free PMC Article
    2. S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis. Tehlivets O, et al. FEBS Lett, 2004 Nov 19. PMID 15556636
    3. Homocysteine regulates fatty acid and lipid metabolism in yeast. Visram M, et al. J Biol Chem, 2018 Apr 13. PMID 29414770, Free PMC Article
    4. Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Shevchenko A, et al. Proc Natl Acad Sci U S A, 1996 Dec 10. PMID 8962070, Free PMC Article
    5. S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis. Malanovic N, et al. J Biol Chem, 2008 Aug 29. PMID 18591246, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cells with down-regulated Sah1 activity major alterations in the expression of the INO1 gene as well as in the localization of Opi1, a negative regulatory factor of phospholipid synthesis
      Title: S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables adenosylhomocysteinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenosylhomocysteinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenosylhomocysteinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in S-adenosylmethionine cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosylhomocysteinase
    NP_010961.3
    • S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      235770..237119 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178934.3 → NP_010961.3  TPA: adenosylhomocysteinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010961.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLU3, P39954
      UniProtKB/TrEMBL
      A6ZQZ2, B3LS56, B5VHH7, C7GSJ0, C8Z746, G2WCS6, N1P540
      Conserved Domains (1) summary
      smart00996
      Location:9 → 448
      AdoHcyase; S-adenosyl-L-homocysteine hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39954.1

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