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    SNU13 RNA binding protein SNU13 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856687, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SNU13
    Official Full Name
    RNA binding protein SNU13
    Primary source
    SGD:S000000752
    Locus tag
    YEL026W
    See related
    AllianceGenome:SGD:S000000752; FungiDB:YEL026W; VEuPathDB:YEL026W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U3 snoRNA binding activity and U4 snRNA binding activity. Involved in mRNA splicing, via spliceosome and maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of U4/U6 x U5 tri-snRNP complex; box C/D methylation guide snoRNP complex; and small-subunit processome. Used to study cancer. Orthologous to human SNU13 (small nuclear ribonucleoprotein 13). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SNU13 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (101943..102323)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene H(+)-transporting V0 sector ATPase subunit c Neighboring gene uncharacterized protein Neighboring gene ubiquinol--cytochrome-c reductase catalytic subunit RIP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of Snu13p mutations reveals differential interactions with the U4 snRNA and U3 snoRNA. Dobbyn HC, et al. RNA, 2004 Feb. PMID 14730029, Free PMC Article
    2. A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA. Marmier-Gourrier N, et al. RNA, 2003 Jul. PMID 12810916, Free PMC Article
    3. Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs. Oruganti Sv, et al. Biochem Biophys Res Commun, 2005 Jul 29. PMID 15963469
    4. Analysis of pre-mRNA and pre-rRNA processing factor Snu13p structure and mutants. Dobbyn HC, et al. Biochem Biophys Res Commun, 2007 Sep 7. PMID 17631273
    5. The yeast C/D box snoRNA U14 adopts a "weak" K-turn like conformation recognized by the Snu13 core protein in solution. Chagot ME, et al. Biochimie, 2019 Sep. PMID 30914254

    See all (110) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bcd1 is required for interactions with box C/D snoRNAs including RNA binding protein SNU13 (Snu13).
      Title: A conserved Bcd1 interaction essential for box C/D snoRNP biogenesis.
    2. Rsa1p enhances Snu13p binding on the U3 box C/D small nucleolar RNA which is one key element of 90S pre-ribosome.
      Title: Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly.
    3. Identification of residues needed for Snu13p and Rsa1p interaction.
      Title: Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly.
    4. Sequence and structure requirements for efficient association of Rrp9p on the B/C motif were studied in yeast cells by expression of variant U3 snoRNAs and immunoselection assays.
      Title: Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair.
    5. The observed structural differences offer a possible explanation to the observed difference in RNA specificity between Snu13p and L7Ae.
      Title: Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables U4 snRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA binding protein SNU13
    NP_010888.1
    • RNA binding protein; part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      101943..102323
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178841.1 → NP_010888.1  TPA: RNA binding protein SNU13 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010888.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLM2, P39990
      UniProtKB/TrEMBL
      A6ZQS2, B3LRY9, C7GX16, C8Z6X1, G2WCK5, N1PA74
      Conserved Domains (1) summary
      cd21104
      Location:5 → 126
      SNU13; U4/U6.U5 small nuclear ribonucleoprotein SNU13
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39990.1

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