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    MHF2 Mhf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1466431, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MHF2
    Official Full Name
    Mhf2p
    Primary source
    SGD:S000028520
    Locus tag
    YDL160C-A
    See related
    AllianceGenome:SGD:S000028520; FungiDB:YDL160C-A; VEuPathDB:YDL160C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in DNA damage response. Part of FANCM-MHF complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MHF2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (169366..169608, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene DNA ligase (ATP) CDC9 Neighboring gene epsin Neighboring gene DExD/H-box ATP-dependent RNA helicase DHH1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae MHF complex structurally resembles the histones (H3-H4)₂ heterotetramer and functions as a heterotetramer. Yang H, et al. Structure, 2012 Feb 8. PMID 22325783
    2. Selective modulation of the functions of a conserved DNA motor by a histone fold complex. Xue X, et al. Genes Dev, 2015 May 15. PMID 25956905, Free PMC Article
    3. Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Xue X, et al. Genes Dev, 2016 Mar 15. PMID 26966246, Free PMC Article
    4. Genetic and physical interactions between the yeast ELG1 gene and orthologs of the Fanconi anemia pathway. Singh S, et al. Cell Cycle, 2013 May 15. PMID 23624835, Free PMC Article
    5. Binding of the Fkh1 Forkhead Associated Domain to a Phosphopeptide within the Mph1 DNA Helicase Regulates Mating-Type Switching in Budding Yeast. Dummer AM, et al. PLoS Genet, 2016 Jun. PMID 27257873, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here we report the structure of Saccharomyces cerevisiae MHF complex in which MHF1 and MHF2 assume a typical histone fold. [MHF2]
      Title: Saccharomyces cerevisiae MHF complex structurally resembles the histones (H3-H4)₂ heterotetramer and functions as a heterotetramer.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FANCM-MHF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of FANCM-MHF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mhf2p
    NP_878060.1
    • Component of the heterotetrameric MHF histone-fold complex; in humans the MHF complex interacts with both DNA and Mph1p ortholog FANCM to stabilize and remodel blocked replication forks and repair damaged DNA; mhf2 srs2 double mutants are MMS hypersensitive; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-X, also known as MHF2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      169366..169608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184530.1 → NP_878060.1  TPA: Mhf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878060.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRI9, Q3E829
      UniProtKB/TrEMBL
      A6ZXG8, B3LH48, C7GL10, C8Z6E2, G2WC02, N1PAM3
      Conserved Domains (1) summary
      pfam09415
      Location:4 → 79
      CENP-X; CENP-S associating Centromere protein X
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E829.1

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