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    SNR45 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 9164982, updated on 28-Oct-2024

    Summary

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    Official Symbol
    SNR45
    Primary source
    SGD:S000006505
    Locus tag
    YNCP0021W
    See related
    AllianceGenome:SGD:S000006505
    Gene type
    ncRNA
    RNA name
    snoRNA
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables small ribosomal subunit rRNA binding activity. Involved in rRNA acetylation. Part of box C/D methylation guide snoRNP complex. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See SNR45 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (821732..821903)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene ribosome biosynthesis protein NOC4 Neighboring gene asparagine synthase (glutamine-hydrolyzing) 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the interaction between protein Snu13p/15.5K and the Rsa1p/NUFIP factor and demonstration of its functional importance for snoRNP assembly. Rothé B, et al. Nucleic Acids Res, 2014 Feb. PMID 24234454, Free PMC Article
    2. Specialized box C/D snoRNPs act as antisense guides to target RNA base acetylation. Sharma S, et al. PLoS Genet, 2017 May. PMID 28542199, Free PMC Article
    3. Yeast Nrd1, Nab3, and Sen1 transcriptome-wide binding maps suggest multiple roles in post-transcriptional RNA processing. Jamonnak N, et al. RNA, 2011 Nov. PMID 21954178, Free PMC Article
    4. A common core RNP structure shared between the small nucleoar box C/D RNPs and the spliceosomal U4 snRNP. Watkins NJ, et al. Cell, 2000 Oct 27. PMID 11081632
    5. New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. Piekna-Przybylska D, et al. RNA, 2007 Mar. PMID 17283215, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    • C/D box small nucleolar RNA (snoRNA); acts as antisense guide to target RNA base acetylation by Kre33p to cytosine 1773 in 18S rRNA (responsible for ac4C 1773); establishes extended bipartite complementarity around the cytosines targeted for acetylation, similar to pseudouridylation pocket formation by the H/ACA snoRNPs; base pairing between snR45 and 18S rRNA requires the putative helicase activity of Kre33p

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables small ribosomal subunit rRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in rRNA acetylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of box C/D methylation guide snoRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      821732..821903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. NR_132271.1 RNA Sequence

      Status: REVIEWED

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