POR1 porin POR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: POR1
Official Full Name: porin POR1
Primary source: SGD:S000005000
Locus tag: YNL055C
See related: AllianceGenome:SGD:S000005000; FungiDB:YNL055C; VEuPathDB:YNL055C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: OMP2
Summary: Enables phospholipid scramblase activity; ubiquinone binding activity; and voltage-gated monoatomic anion channel activity. Involved in several processes, including DNA transport; cell redox homeostasis; and positive regulation of protein import into nucleus. Located in mitochondrial inner-outer membrane contact site. Is active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including VDAC1 (voltage dependent anion channel 1) and VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See POR1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (517994..518845, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The small yeast GTPase Rho5 requires specific mitochondrial outer membrane proteins for translocation under oxidative stress and interacts with the VDAC Por1.
Title: The small yeast GTPase Rho5 requires specific mitochondrial outer membrane proteins for translocation under oxidative stress and interacts with the VDAC Por1.
Porin serves distinct functions as outer membrane channel for metabolites and as coupling factor for protein translocation into the inner membrane.
Title: Dual Role of Mitochondrial Porin in Metabolite Transport across the Outer Membrane and Protein Transfer to the Inner Membrane.
Por1 appears to contribute to cell-cycle-dependent variation of the functional trimeric TOM complex by chaperoning monomeric Tom22, which arises from the cell-cycle-controlled variation of phosphorylated Tom6.
Title: Porin Associates with Tom22 to Regulate the Mitochondrial Protein Gate Assembly.
As a first step toward identifying the actual molecular/enzymatic function of Gup1, this work identified by co-immunoprecipitation the yeast mitochondria membrane VDAC1/Por1 as a physical partner of Gup1.
Title: Saccharomyces cerevisiae mitochondrial Por1/yVDAC1 (voltage-dependent anion channel 1) interacts physically with the MBOAT O-acyltransferase Gup1/HHATL in the control of cell wall integrity and programmed cell death.
Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by approximately 90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria.
Title: Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast.
Data show that transformation of voltage dependent anion channel VDAC1 (Deltapor1) yeast with human Cu/Zn superoxide dismutase (SOD1) completely restores the cell growth deficit.
Title: Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes.
Por1 contributes to Snf1 activation.
Title: Mitochondrial porin Por1 and its homolog Por2 contribute to the positive control of Snf1 protein kinase in Saccharomyces cerevisiae.
The protective role of cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p).
Title: The protective role of yeast cathepsin D in acetic acid-induced apoptosis depends on ANT (Aac2p) but not on the voltage-dependent channel (Por1p).
Yeast POR1 orientation in vivo is reported.
Title: Probing the orientation of yeast VDAC1 in vivo.
study has shown that both cytosol & mitochondria redox states depend on the presence of a given VDAC isoform; cytosol redox state is mediated by VDAC1 (POR1), although VDAC2 has a quantitative effect; mitochondria redox state depends on both VDAC isoforms
Title: Redox regulation of protein expression in Saccharomyces cerevisiae mitochondria: possible role of VDAC.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables phospholipid scramblase activity	IDA Inferred from Direct Assay more info	PubMed
enables porin activity	IEA Inferred from Electronic Annotation more info
enables ubiquinone binding	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic anion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated monoatomic anion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic anion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic anion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane phospholipid scrambling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in mitochondrial inner-outer membrane contact site	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrial outer membrane	HDA more info	PubMed
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IPI Inferred from Physical Interaction more info	PubMed
part_of pore complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: porin POR1

NP_014343.1

Mitochondrial porin and phospholipid scramblase; voltage-dependent anion channel in the outer mitochondrial membrane (OMM) required for maintenance of mitochondrial osmotic stability and membrane permeability; scramblase involved in mitochondrial transbilayer translocation of phospholipids; couples glutathione pools of the intermembrane space (IMS) and the cytosol; phosphorylated; protein abundance increases in response to DNA replication stress; orthologous to human VDAC1 and VDAC2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

517994..518845 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182894.1 → NP_014343.1 TPA: porin POR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014343.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1C3, P04840

UniProtKB/TrEMBL

A6ZS23, B3LNR6, C7GLU6, C8ZGH3, G2WM48, N1NY08

Conserved Domains (1) summary

cd07306
Location:3 → 282

Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane