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    Cops3 COP9 signalosome subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287367, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cops3provided by RGD
    Official Full Name
    COP9 signalosome subunit 3provided by RGD
    Primary source
    RGD:1303002
    See related
    EnsemblRapid:ENSRNOG00000053943 AllianceGenome:RGD:1303002
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein deneddylation; regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of COP9 signalosome. Orthologous to human COPS3 (COP9 signalosome subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 480.7), Heart (RPKM 340.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cops3 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45117664..45151868, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44618115..44652807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46182680..46206083, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene folliculin Neighboring gene dCTP pyrophosphatase 1, pseudogene 1 Neighboring gene U1 spliceosomal RNA Neighboring gene 5',3'-nucleotidase, mitochondrial Neighboring gene mediator complex subunit 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. COP9 signalosome subunit 3 is essential for maintenance of cell proliferation in the mouse embryonic epiblast. Yan J, et al. Mol Cell Biol, 2003 Oct. PMID 12972600, Free PMC Article
    2. Symmetrical modularity of the COP9 signalosome complex suggests its multifunctionality. Sharon M, et al. Structure, 2009 Jan 14. PMID 19141280
    3. The COP9 complex is conserved between plants and mammals and is related to the 26S proteasome regulatory complex. Wei N, et al. Curr Biol, 1998 Jul 30-Aug 13. PMID 9707402
    4. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article
    5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94156

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein deneddylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COP9 signalosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome complex subunit 3
    Names
    COP9 (constitutive photomorphogenic) homolog, subunit 3
    SGN3
    signalosome subunit 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004200.1 → NP_001004200.1  COP9 signalosome complex subunit 3

      See identical proteins and their annotated locations for NP_001004200.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079143
      UniProtKB/Swiss-Prot
      Q68FW9
      UniProtKB/TrEMBL
      A0A8I5Y8F4
      Related
      ENSRNOP00000069208.1, ENSRNOT00000091471.3
      Conserved Domains (1) summary
      pfam01399
      Location:259 → 362
      PCI; PCI domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      45117664..45151868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085398.2 → XP_038941326.2  COP9 signalosome complex subunit 3 isoform X1

      Related
      ENSRNOP00000109659.1, ENSRNOT00000168377.1

    2. XM_039085399.2 → XP_038941327.1  COP9 signalosome complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y8F4
      Conserved Domains (1) summary
      pfam01399
      Location:239 → 342
      PCI; PCI domain

    3. XM_063268611.1 → XP_063124681.1  COP9 signalosome complex subunit 3 isoform X1

    4. XM_017597079.3 → XP_017452568.1  COP9 signalosome complex subunit 3 isoform X3

      Conserved Domains (1) summary
      pfam01399
      Location:129 → 232
      PCI; PCI domain

    5. XM_063268612.1 → XP_063124682.1  COP9 signalosome complex subunit 3 isoform X2

    RNA

    1. XR_005489723.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68FW9.1 GenPept UniProtKB/Swiss-Prot:Q68FW9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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