taf-4 Transcription initiation factor TFIID subunit 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: taf-4
Official Full Name: Transcription initiation factor TFIID subunit 4
Primary source: WormBase:WBGene00006385
Locus tag: CELE_R119.6
See related: AllianceGenome:WB:WBGene00006385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable DNA binding activity. Predicted to contribute to RNA polymerase II general transcription initiation factor activity. Involved in several processes, including determination of adult lifespan; regulation of mitotic cell cycle, embryonic; and transcription initiation at RNA polymerase II promoter. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder and spermatogenic failure 13. Orthologous to several human genes including TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See taf-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (382826..388564)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAF-4 and HIF-1 may be part of a general signaling axis that specifies Mit mutant life extension
Title: TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.
Study shows that OMA-1 and OMA-2, previously shown to regulate oocyte maturation, repress transcription in P0 and P1 by binding to and sequestering in the cytoplasm TAF-4, a component critical for assembly of TFIID and the pol II preinitiation complex.
Title: Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4.
important for a significant fraction of transcription, apparently not essential for the expression of multiple developmental and other metazoan-specific genes
Title: A broad but restricted requirement for TAF-5 (human TAFII100) for embryonic transcription in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R119.6 (e-PCR)
- UniSTS:314821

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II general transcription initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle, embryonic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Transcription initiation factor TFIID subunit 4

NP_490728.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

382826..388564

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058327.9 → NP_490728.2 Transcription initiation factor TFIID subunit 4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490728.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O61707

Conserved Domains (2) summary

cd08045
Location:299 → 509

TAF4; TATA Binding Protein (TBP) Associated Factor 4 (TAF4) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex

smart00549
Location:103 → 196

TAFH; TAF homology