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    xpo-2 Exportin-2;Exportin-2 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171621, updated on 12-Jun-2024

    Summary

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    Gene symbol
    xpo-2
    Gene description
    Exportin-2;Exportin-2 C-terminal domain-containing protein
    Locus tag
    CELE_Y48G1A.5
    See related
    AllianceGenome:WB:WBGene00002079
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nuclear export signal receptor activity. Predicted to be involved in protein export from nucleus and protein import into nucleus. Predicted to be active in cytosol and nuclear envelope. Orthologous to human CSE1L (chromosome segregation 1 like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See xpo-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (318549..323352, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Importin N-terminal domain-containing protein Neighboring gene pseudo Neighboring gene Nucleolar protein 14 Neighboring gene Dauer abnormal formation protein 25

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article
    2. Functional genomic analysis of RNA interference in C. elegans. Kim JK, et al. Science, 2005 May 20. PMID 15790806
    3. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
    4. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    5. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables nuclear export signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Exportin-2;Exportin-2 C-terminal domain-containing protein
    NP_001293261.1
    • Confirmed by transcript evidence
    NP_490716.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      318549..323352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058315.7 → NP_490716.1  Exportin-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q965V4
      Conserved Domains (2) summary
      COG5657
      Location:3 → 799
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]
      pfam08506
      Location:150 → 513
      Cse1

    2. NM_001306332.3 → NP_001293261.1  Exportin-2 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CKP0
      Conserved Domains (1) summary
      pfam03378
      Location:4 → 89
      CAS_CSE1; CAS/CSE protein, C-terminus
    Nucleotide Protein
    Heading Accession and Version

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