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    gon-2 LSDAT_euk domain-containing protein;Transient receptor potential channel [ Caenorhabditis elegans ]

    Gene ID: 172646, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gon-2
    Official Full Name
    LSDAT_euk domain-containing protein;Transient receptor potential channel
    Primary source
    WormBase:WBGene00001651
    Locus tag
    CELE_T01H8.5
    See related
    AllianceGenome:WB:WBGene00001651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cation channel activity. Involved in defecation; gonad development; and mitotic cell cycle. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in excretory cell; gonad; intestine; pharynx; and rectal epithelium. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; congenital stationary night blindness; congenital stationary night blindness 1C; intestinal hypomagnesemia 1; and metal metabolism disorder. Orthologous to several human genes including TRPM3 (transient receptor potential cation channel subfamily M member 3) and TRPM7 (transient receptor potential cation channel subfamily M member 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See gon-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    30
    Sequence:
    Chromosome: I; NC_003279.8 (8549519..8570998, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-serine ammonia-lyase Neighboring gene Putative ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression. West RJ, et al. Gene, 2001 Mar 21. PMID 11290424
    2. Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans. Kemp BJ, et al. Genetics, 2009 Feb. PMID 19087963, Free PMC Article
    3. Highly Ca2+-selective TRPM channels regulate IP3-dependent oscillatory Ca2+ signaling in the C. elegans intestine. Xing J, et al. J Gen Physiol, 2008 Mar. PMID 18299395, Free PMC Article
    4. TRPM channel function in Caenorhabditis elegans. Baylis HA, et al. Biochem Soc Trans, 2007 Feb. PMID 17233618
    5. Diethylcarbamazine activates TRP channels including TRP-2 in filaria, Brugia malayi. Verma S, et al. Commun Biol, 2020 Jul 28. PMID 32724078, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the activity of GTL-2 balances the activities of the paralogous TRPM channel proteins, GON-2 and GTL-1
      Title: Magnesium excretion in C. elegans requires the activity of the GTL-2 TRPM channel.
    2. PIP(2)-dependent regulation of GON-2/GTL-1 may provide a mechanism to coordinate plasma membrane Ca(2+) influx with PLCgamma and IP(3) receptor activity as well as intracellular Ca(2+) store depletion.
      Title: Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling.
    3. Inactivation of gem-1 enhances the gonadogenesis defects of gon-2 hypomorphic mutations, suggesting that these two genes probably act in parallel to promote gonadal cell divisions.
      Title: Gem-1 encodes an SLC16 monocarboxylate transporter-related protein that functions in parallel to the gon-2 TRPM channel during gonad development in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables monoatomic cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic cation transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defecation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defecation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LSDAT_euk domain-containing protein;Transient receptor potential channel
    NP_001122505.1
    • Confirmed by transcript evidence
    NP_001122506.1
    • Confirmed by transcript evidence
    NP_001129788.1
    • Confirmed by transcript evidence
    NP_001359707.1
    • Confirmed by transcript evidence
    NP_492315.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8549519..8570998 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059914.8 → NP_492315.4  Transient receptor potential channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492315.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P91909, Q93971
      UniProtKB/TrEMBL
      Q8IG04
      Conserved Domains (2) summary
      pfam00520
      Location:1328 → 1567
      Ion_trans; Ion transport protein
      pfam07695
      Location:1299 → 1462
      7TMR-DISM_7TM; 7TM diverse intracellular signalling

    2. NM_001373178.2 → NP_001359707.1  LSDAT_euk domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE91, Q8IG04
      Conserved Domains (2) summary
      pfam00520
      Location:1207 → 1466
      Ion_trans; Ion transport protein
      pfam18139
      Location:291 → 555
      LSDAT_euk; SLOG in TRPM

    3. NM_001129034.3 → NP_001122506.1  LSDAT_euk domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122506.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGP7, Q8IG04
      Conserved Domains (2) summary
      pfam00520
      Location:1267 → 1506
      Ion_trans; Ion transport protein
      pfam07695
      Location:1238 → 1401
      7TMR-DISM_7TM; 7TM diverse intracellular signalling

    4. NM_001136316.4 → NP_001129788.1  LSDAT_euk domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGJ6, Q8IG04
      Conserved Domains (1) summary
      pfam00520
      Location:922 → 1161
      Ion_trans; Ion transport protein

    5. NM_001129033.3 → NP_001122505.1  Transient receptor potential channel [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYU8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93971.4

    Gene LinkOut

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