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    NOT3 CCR4-NOT core subunit NOT3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854773, updated on 9-Jun-2024

    Summary

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    Gene symbol
    NOT3
    Gene description
    CCR4-NOT core subunit NOT3
    Primary source
    FungiDB:YIL038C
    Locus tag
    YIL038C
    See related
    SGD:S000001300; AllianceGenome:SGD:S000001300; VEuPathDB:YIL038C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in positive regulation of RNA metabolic process and protein ubiquitination. Located in cytoplasm. Part of CCR4-NOT core complex. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOT3 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (280142..282652, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Apq12p Neighboring gene Ted1p Neighboring gene pheromone-regulated protein PRM2 Neighboring gene Cst6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization. Collart MA, et al. Genes Dev, 1994 Mar 1. PMID 7926748
    2. Characterization of NOT5 that encodes a new component of the Not protein complex. Oberholzer U, et al. Gene, 1998 Jan 19. PMID 9511744
    3. The deadenylase components Not2p, Not3p, and Not5p promote mRNA decapping. Alhusaini N, et al. RNA, 2016 May. PMID 26952104, Free PMC Article
    4. Structure and RNA-binding properties of the Not1-Not2-Not5 module of the yeast Ccr4-Not complex. Bhaskar V, et al. Nat Struct Mol Biol, 2013 Nov. PMID 24121231
    5. The CCR4-NOT Complex Maintains Stability and Transcription of rRNA Genes by Repressing Antisense Transcripts. Hosoyamada S, et al. Mol Cell Biol, 2019 Dec 11. PMID 31611247, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA poly(A) tail shortening IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of CCR4-NOT core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT core subunit NOT3
    NP_012226.3
    • Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      280142..282652 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179388.3 → NP_012226.3  TPA: CCR4-NOT core subunit NOT3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012226.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVP4, P06102, Q6B233
      UniProtKB/TrEMBL
      A0A8H4F9P4, G2WGA8, N1P1N3
      Conserved Domains (3) summary
      PHA03247
      Location:293 → 399
      PHA03247; large tegument protein UL36; Provisional
      pfam04065
      Location:2 → 230
      Not3; Not1 N-terminal domain, CCR4-Not complex component
      pfam04153
      Location:691 → 782
      NOT2_3_5; NOT2 / NOT3 / NOT5 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06102.2

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