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    CHZ1 Chz1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856752, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CHZ1
    Official Full Name
    Chz1p
    Primary source
    SGD:S000000832
    Locus tag
    YER030W
    See related
    AllianceGenome:SGD:S000000832; FungiDB:YER030W; VEuPathDB:YER030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables histone binding activity. Involved in chromatin remodeling. Is active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CHZ1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (213437..213898)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Mig3p Neighboring gene mRNA splicing protein SMB1 Neighboring gene Rab family GTPase YPT31 Neighboring gene Fir1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping. Begley TJ, et al. Mol Cancer Res, 2002 Dec. PMID 12496357
    2. Histone chaperone Chz1 facilitates the disfavouring property of Spt16 to H2A.Z-containing genes in Saccharomyces cerevisiae. Liu H, et al. Biochem J, 2014 Jun 15. PMID 24707933
    3. Distinct roles for histone chaperones in the deposition of Htz1 in chromatin. Liu H, et al. Biosci Rep, 2014 Sep 19. PMID 25338502, Free PMC Article
    4. NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B. Zhou Z, et al. Nat Struct Mol Biol, 2008 Aug. PMID 18641662, Free PMC Article
    5. Binding kinetics of histone chaperone Chz1 and variant histone H2A.Z-H2B by relaxation dispersion NMR spectroscopy. Hansen DF, et al. J Mol Biol, 2009 Mar 20. PMID 19385041, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results define the distinct roles for histone chaperones Chz1 and Nap1 to regulate Htz1 incorporation into chromatin.
      Title: Distinct roles for histone chaperones in the deposition of Htz1 in chromatin.
    2. results suggest that the discrimination of Spt16 to Htz1-bound genes is due to the priority of Chz1 over Spt16 in binding to the Htz1-bound genomic regions; Chz1-escorted Htz1 therefore impairs Spt16 binding at chromatin
      Title: Histone chaperone Chz1 facilitates the disfavouring property of Spt16 to H2A.Z-containing genes in Saccharomyces cerevisiae.
    3. the histone chaperones Nap1 and Chz1 have separate Htz1-dependent and -independent functions
      Title: Nap1 and Chz1 have separate Htz1 nuclear import and assembly functions.
    4. analysis of the NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B
      Title: NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
    5. Chz1 is a histone chaperone protein that has preference for histone H2AZ.
      Title: Chz1, a nuclear chaperone for histone H2AZ.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables histone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Chz1p
    NP_010947.2
    • Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      213437..213898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178921.1 → NP_010947.2  TPA: Chz1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010947.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLS9, P40019
      UniProtKB/TrEMBL
      G2WCR3, N1P6V3
      Conserved Domains (1) summary
      pfam09649
      Location:97 → 120
      CHZ; Histone chaperone domain CHZ
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40019.2

    Gene LinkOut

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