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    RDS3 U2 snRNP complex subunit RDS3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856209, updated on 7-Jul-2024

    Summary

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    Gene symbol
    RDS3
    Gene description
    U2 snRNP complex subunit RDS3
    Primary source
    FungiDB:YPR094W
    Locus tag
    YPR094W
    See related
    SGD:S000006298; AllianceGenome:SGD:S000006298; VEuPathDB:YPR094W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in response to xenobiotic stimulus and spliceosomal complex assembly. Part of U2 snRNP. Orthologous to human PHF5A (PHD finger protein 5A). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RDS3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (720637..720960)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ubiquitin-protein ligase ASR1 Neighboring gene Arf family guanine nucleotide exchange factor SYT1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Solution structure of the U2 snRNP protein Rds3p reveals a knotted zinc-finger motif. van Roon AM, et al. Proc Natl Acad Sci U S A, 2008 Jul 15. PMID 18621724, Free PMC Article
    2. Rds3p is required for stable U2 snRNP recruitment to the splicing apparatus. Wang Q, et al. Mol Cell Biol, 2003 Oct. PMID 14517302, Free PMC Article
    3. New regulators of drug sensitivity in the family of yeast zinc cluster proteins. Akache B, et al. J Biol Chem, 2002 Jun 14. PMID 11943786
    4. Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Rauhut R, et al. Science, 2016 Sep 23. PMID 27562955
    5. Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing. Dziembowski A, et al. EMBO J, 2004 Dec 8. PMID 15565172, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP complex subunit RDS3
    NP_015419.1
    • Component of the SF3b subcomplex of the U2 snRNP; zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      720637..720960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184191.1 → NP_015419.1  TPA: U2 snRNP complex subunit RDS3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015419.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W493, Q06835
      UniProtKB/TrEMBL
      A0A6A5Q1K7, A6ZWX6, B3LK60, C7GPT4, C8ZJB7, G2WPR2, N1NW34
      Conserved Domains (1) summary
      pfam03660
      Location:1 → 105
      PHF5; PHF5-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06835.1

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