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    SYT1 Arf family guanine nucleotide exchange factor SYT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856210, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SYT1
    Official Full Name
    Arf family guanine nucleotide exchange factor SYT1
    Primary source
    SGD:S000006299
    Locus tag
    YPR095C
    See related
    AllianceGenome:SGD:S000006299; FungiDB:YPR095C; VEuPathDB:YPR095C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including positive regulation of ARF protein signal transduction; protein localization to Golgi apparatus; and response to endoplasmic reticulum stress. Located in Golgi membrane. Orthologous to several human genes including PSD (pleckstrin and Sec7 domain containing); PSD2 (pleckstrin and Sec7 domain containing 2); and PSD3 (pleckstrin and Sec7 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SYT1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (721037..724717, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase ASR1 Neighboring gene U2 snRNP complex subunit RDS3 Neighboring gene uncharacterized protein Neighboring gene Lec1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unfolded protein response regulates yeast small GTPase Arl1p activation at late Golgi via phosphorylation of Arf GEF Syt1p. Hsu JW, et al. Proc Natl Acad Sci U S A, 2016 Mar 22. PMID 26966233, Free PMC Article
    2. Genetic interactions in yeast between Ypt GTPases and Arf guanine nucleotide exchangers. Jones S, et al. Genetics, 1999 Aug. PMID 10430582, Free PMC Article
    3. Syt1p promotes activation of Arl1p at the late Golgi to recruit Imh1p. Chen KY, et al. J Cell Sci, 2010 Oct 15. PMID 20841378
    4. Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. Audhya A, et al. EMBO J, 2004 Oct 1. PMID 15372071, Free PMC Article
    5. Large-scale investigation of oxygen response mutants in Saccharomyces cerevisiae. Samanfar B, et al. Mol Biosyst, 2013 Jun. PMID 23467670

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of ARF protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ARF protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ARF protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Arf family guanine nucleotide exchange factor SYT1
    NP_015420.1
    • Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      721037..724717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184192.1 → NP_015420.1  TPA: Arf family guanine nucleotide exchange factor SYT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W494, Q06836
      UniProtKB/TrEMBL
      B3LK61, N1NVK8
      Conserved Domains (1) summary
      COG5307
      Location:141 → 1221
      COG5307; Guanine-nucleotide exchange factor, contains Sec7 domain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06836.1

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