GRS2 putative glycine--tRNA ligase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GRS2
Official Full Name: putative glycine--tRNA ligase
Primary source: SGD:S000006285
Locus tag: YPR081C
See related: AllianceGenome:SGD:S000006285; FungiDB:YPR081C; VEuPathDB:YPR081C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glycine-tRNA ligase activity. Involved in glycyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2D and autosomal dominant distal hereditary motor neuronopathy 5. Orthologous to human GARS1 (glycyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See GRS2 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (702114..703970, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A phylogenetic analysis further showed that GRS1 and GRS2 are paralogues that arose from a gene duplication event relatively recently, with GRS1 being the predecessor.
Title: An insertion peptide in yeast glycyl-tRNA synthetase facilitates both productive docking and catalysis of cognate tRNAs.
GRS2 rescued the growth defect of a GRS1 knockout strain when expressed at 37 degrees C, but not at 30 degrees C. These results suggest that GRS2 is actually an inducible gene that may function to rescue the activity of GRS1 under stress conditions.
Title: Saccharomyces cerevisiae possesses a stress-inducible glycyl-tRNA synthetase gene.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP:ATP adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity, acting on a tRNA	IEA Inferred from Electronic Annotation more info
enables glycine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables glycine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables glycine-tRNA ligase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in glycyl-tRNA aminoacylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial glycyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative glycine--tRNA ligase

NP_015406.1

EC 6.1.1.14

Glycine-tRNA synthetase, not expressed under normal growth conditions; expression is induced under heat, oxidative, pH, or ethanol stress conditions; more stable than the major glycine-tRNA synthetase Grs1p at 37 deg C; GRS2 has a paralog, GRS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

702114..703970 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184178.1 → NP_015406.1 TPA: putative glycine--tRNA ligase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015406.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W483, Q06817

UniProtKB/TrEMBL

A6ZWW6, B3LK51, C7GPS4, C8ZJA6, N1NXM5

Conserved Domains (1) summary

TIGR00389
Location:7 → 598

glyS_dimeric; glycyl-tRNA synthetase, dimeric type