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    LEC1 Lec1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856212, updated on 28-Oct-2024

    Summary

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    Official Symbol
    LEC1
    Official Full Name
    Lec1p
    Primary source
    SGD:S000006301
    Locus tag
    YPR097W
    See related
    AllianceGenome:SGD:S000006301; FungiDB:YPR097W; VEuPathDB:YPR097W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatidylinositol binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See LEC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (725394..728615)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Arf family guanine nucleotide exchange factor SYT1 Neighboring gene uncharacterized protein Neighboring gene Tmh18p Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein MRPL51

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. Yu JW, et al. J Biol Chem, 2001 Nov 23. PMID 11557775
    2. The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae. Grunau S, et al. Biochem J, 2011 Feb 15. PMID 21121900
    3. Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution. Castro IG, et al. Elife, 2022 Nov 10. PMID 36354737, Free PMC Article
    4. The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae. Josefson R, et al. Sci Rep, 2023 Jun 7. PMID 37286562, Free PMC Article
    5. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lec1p
    NP_015422.2
    • Phosphoinositide-binding regulator of ergosterol distribution; contains PX (Phox homology) domain; associated with ER-lipid droplet contact site; may facilitate ergosterol transport between plasma membrane and lipid droplets

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      725394..728615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184194.2 → NP_015422.2  TPA: Lec1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015422.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W496, Q06839
      UniProtKB/TrEMBL
      C8ZJB9, N1P295
      Conserved Domains (3) summary
      cd06869
      Location:201 → 502
      PX_UP2_fungi; The phosphoinositide binding Phox Homology domain of uncharacterized fungal proteins
      pfam12825
      Location:567 → 917
      DUF3818; Domain of unknown function in PX-proteins (DUF3818)
      pfam12828
      Location:6 → 149
      PXB; PX-associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06839.2

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