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    Mrps2 mitochondrial ribosomal protein S2 [ Mus musculus (house mouse) ]

    Gene ID: 118451, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrps2provided by MGI
    Official Full Name
    mitochondrial ribosomal protein S2provided by MGI
    Primary source
    MGI:MGI:2153089
    See related
    Ensembl:ENSMUSG00000035772 AllianceGenome:MGI:2153089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500019M10Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial ribosome assembly and mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including cerebral cortex; early conceptus; gonad; heart; and liver. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 36. Orthologous to human MRPS2 (mitochondrial ribosomal protein S2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 23.2), adrenal adult (RPKM 20.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrps2 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28355963..28361189)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28465951..28471177)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13373 Neighboring gene STARR-seq mESC enhancer starr_04019 Neighboring gene protein phosphatase 1, regulatory subunit 26 Neighboring gene STARR-seq mESC enhancer starr_04020 Neighboring gene piercer of microtubule wall 1 Neighboring gene ribosomal protein SA, pseudogene 9 Neighboring gene globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_04022

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ribosome. The structure of the human mitochondrial ribosome. Amunts A, et al. Science, 2015 Apr 3. PMID 25838379, Free PMC Article
    2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. Suzuki T, et al. J Biol Chem, 2001 Aug 31. PMID 11402041
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
    5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial ribosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial small ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of mitochondrial small ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    small ribosomal subunit protein uS2m
    Names
    28S ribosomal protein S2, mitochondrial
    MRP-S2
    S2mt

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166031.2 → NP_001159503.2  small ribosomal subunit protein uS2m isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK051184, AK077219
      UniProtKB/TrEMBL
      Q8BQ99
      Conserved Domains (1) summary
      cd01425
      Location:62 → 237
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

    2. NM_080452.3 → NP_536700.3  small ribosomal subunit protein uS2m isoform 1

      See identical proteins and their annotated locations for NP_536700.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK051184, AK077219
      Consensus CDS
      CCDS15838.1
      UniProtKB/Swiss-Prot
      A2AK29, Q3TMF8, Q924T2
      UniProtKB/TrEMBL
      Q8BQ99
      Related
      ENSMUSP00000036725.4, ENSMUST00000038600.4
      Conserved Domains (1) summary
      cd01425
      Location:81 → 256
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28355963..28361189
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497625.3 → XP_006497688.1  small ribosomal subunit protein uS2m isoform X1

      See identical proteins and their annotated locations for XP_006497688.1

      UniProtKB/TrEMBL
      Q8BQ99
      Conserved Domains (1) summary
      cd01425
      Location:127 → 302
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

    2. XM_030246830.1 → XP_030102690.1  small ribosomal subunit protein uS2m isoform X3

      Related
      ENSMUST00000146332.2
      Conserved Domains (1) summary
      cd01425
      Location:1 → 158
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

    3. XM_036157666.1 → XP_036013559.1  small ribosomal subunit protein uS2m isoform X2

      Conserved Domains (1) summary
      cd01425
      Location:3 → 160
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...

    4. XM_036157667.1 → XP_036013560.1  small ribosomal subunit protein uS2m isoform X2

      Conserved Domains (1) summary
      cd01425
      Location:3 → 160
      RPS2; Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924T2.1 GenPept UniProtKB/Swiss-Prot:Q924T2

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