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    SRB7 Srb7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851903, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SRB7
    Gene description
    Srb7p
    Primary source
    FungiDB:YDR308C
    Locus tag
    YDR308C
    See related
    SGD:S000002716; AllianceGenome:SGD:S000002716; VEuPathDB:YDR308C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MED21; SSX1
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Part of core mediator complex and mediator complex. Orthologous to human MED21 (mediator complex subunit 21). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SRB7 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1078027..1078449, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene Gic2p Neighboring gene Sum1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Srb7p is essential for the activation of a subset of genes. Gromöller A, et al. FEBS Lett, 2000 Oct 27. PMID 11056220
    2. An RNA polymerase II holoenzyme responsive to activators. Koleske AJ, et al. Nature, 1994 Mar 31. PMID 8133894
    3. Srb7p is a physical and physiological target of Tup1p. Gromöller A, et al. EMBO J, 2000 Dec 15. PMID 11118219, Free PMC Article
    4. General requirement for RNA polymerase II holoenzymes in vivo. Thompson CM, et al. Proc Natl Acad Sci U S A, 1995 May 9. PMID 7753848, Free PMC Article
    5. Cell cycle-specific expression of the SWI4 transcription factor is required for the cell cycle regulation of HO transcription. Breeden L, et al. Genes Dev, 1991 Jul. PMID 2065973

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription corepressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Srb7p
    NP_010594.3
    • Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1078027..1078449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180616.3 → NP_010594.3  TPA: Srb7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010594.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VST7, P47822
      UniProtKB/TrEMBL
      A0A6A5Q418, A6ZYQ6, B3LFY8, C7GQV8, C8Z5L9, G2WB46, N1PAH5
      Conserved Domains (1) summary
      pfam11221
      Location:1 → 131
      Med21; Subunit 21 of Mediator complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47822.1

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