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    PUT1 proline dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850833, updated on 9-Jun-2024

    Summary

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    Gene symbol
    PUT1
    Gene description
    proline dehydrogenase
    Primary source
    FungiDB:YLR142W
    Locus tag
    YLR142W
    See related
    SGD:S000004132; AllianceGenome:SGD:S000004132; VEuPathDB:YLR142W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables proline dehydrogenase activity. Involved in proline catabolic process to glutamate. Located in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1) and PRODH2 (proline dehydrogenase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PUT1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (425186..426616)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Sls1p Neighboring gene Rrn5p Neighboring gene tRNA-Asp Neighboring gene diphthine--ammonia ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of Put1p from Saccharomyces cerevisiae. Wanduragala S, et al. Arch Biochem Biophys, 2010 Jun 15. PMID 20450881, Free PMC Article
    2. Tomato QM-like protein protects Saccharomyces cerevisiae cells against oxidative stress by regulating intracellular proline levels. Chen C, et al. Appl Environ Microbiol, 2006 Jun. PMID 16751508, Free PMC Article
    3. Proline utilization in Saccharomyces cerevisiae: sequence, regulation, and mitochondrial localization of the PUT1 gene product. Wang SS, et al. Mol Cell Biol, 1987 Dec. PMID 3125423, Free PMC Article
    4. Longevity Regulation by Proline Oxidation in Yeast. Nishimura A, et al. Microorganisms, 2021 Aug 2. PMID 34442729, Free PMC Article
    5. Improving freeze-tolerance of baker's yeast through seamless gene deletion of NTH1 and PUT1. Dong J, et al. J Ind Microbiol Biotechnol, 2016 Jun. PMID 26965428

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Purification and characterization of Put1p from Saccharomyces cerevisiae.
      Title: Purification and characterization of Put1p from Saccharomyces cerevisiae.
    2. The phosphorylation of Put3p appears to influence the association of Gat1p, but not Gln3p, to the PUT1 promoter.
      Title: Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables FAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proline dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proline dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proline dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proline catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process to glutamate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proline catabolic process to glutamate IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proline catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline catabolic process to glutamate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proline metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proline dehydrogenase
    NP_013243.1
    • Proline oxidase; nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      425186..426616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182029.1 → NP_013243.1  TPA: proline dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013243.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYD6, P09368
      UniProtKB/TrEMBL
      A0A8H4BY43, A7A140, G2WIY0, N1NZQ2
      Conserved Domains (1) summary
      COG0506
      Location:35 → 467
      PutA; Proline dehydrogenase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09368.2

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