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    COS12 Cos12p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852628, updated on 18-Sep-2024

    Summary

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    Official Symbol
    COS12
    Official Full Name
    Cos12p
    Primary source
    SGD:S000003232
    Locus tag
    YGL263W
    See related
    AllianceGenome:SGD:S000003232; FungiDB:YGL263W; VEuPathDB:YGL263W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See COS12 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (2790..3932)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Barcode Sequencing Screen Identifies SUB1 as a Regulator of Yeast Pheromone Inducible Genes. Sliva A, et al. G3 (Bethesda), 2016 Apr 7. PMID 26837954, Free PMC Article
    2. ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode I, et al. J Mol Biol, 2002 May 31. PMID 12051917
    3. An evolutionary scenario for one of the largest yeast gene families. Despons L, et al. Trends Genet, 2006 Jan. PMID 16269202
    4. ATP-binding cassette transporters and sterol O-acyltransferases interact at membrane microdomains to modulate sterol uptake and esterification. Gulati S, et al. FASEB J, 2015 Nov. PMID 26220175, Free PMC Article
    5. Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres. Jethmalani Y, et al. Life Sci Alliance, 2021 Dec. PMID 34625508, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cos12p
    NP_011251.1
    • Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      2790..3932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181129.1 → NP_011251.1  TPA: Cos12p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011251.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV71, P53053
      UniProtKB/TrEMBL
      A6ZTT1, B5VI82
      Conserved Domains (1) summary
      pfam00674
      Location:70 → 164
      DUP; DUP family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53053.1

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