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    MHT1 S-adenosylmethionine-homocysteine S-methyltransferase MHT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850664, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MHT1
    Official Full Name
    S-adenosylmethionine-homocysteine S-methyltransferase MHT1
    Primary source
    SGD:S000003985
    Locus tag
    YLL062C
    See related
    AllianceGenome:SGD:S000003985; FungiDB:YLL062C; VEuPathDB:YLL062C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables S-adenosylmethionine-homocysteine S-methyltransferase activity. Involved in sulfur amino acid metabolic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; artery disease (multiple); autistic disorder; hematologic cancer (multiple); and hyperhomocysteinemia. Orthologous to human MTR (5-methyltetrahydrofolate-homocysteine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MHT1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (16639..17613, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene seripauperin PAU18 Neighboring gene acetyltransferase Neighboring gene S-methylmethionine permease MMP1 Neighboring gene glutathione transferase GTT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reverse methionine biosynthesis from S-adenosylmethionine in eukaryotic cells. Thomas D, et al. J Biol Chem, 2000 Dec 29. PMID 11013242
    2. Homocysteine methyltransferases Mht1 and Sam4 prevent the accumulation of age-damaged (R,S)-AdoMet in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2010 Jul 2. PMID 20421295, Free PMC Article
    3. Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae. Vinci CR, et al. J Biol Chem, 2007 Mar 23. PMID 17264075
    4. Characterization and functional expression of cDNAs encoding methionine-sensitive and -insensitive homocysteine S-methyltransferases from Arabidopsis. Ranocha P, et al. J Biol Chem, 2000 May 26. PMID 10747987
    5. The nuclear basket proteins Mlp1p and Mlp2p are part of a dynamic interactome including Esc1p and the proteasome. Niepel M, et al. Mol Biol Cell, 2013 Dec. PMID 24152732, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAM4 and MHT1 have roles in recognition of age-damaged (R,S)-adenosyl-L-methionine
      Title: Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables S-adenosylmethionine-homocysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-methylmethionine-homocysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    S-adenosylmethionine-homocysteine S-methyltransferase MHT1
    NP_013038.1
    • S-methylmethionine-homocysteine methyltransferase; functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      16639..17613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181882.1 → NP_013038.1  TPA: S-adenosylmethionine-homocysteine S-methyltransferase MHT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013038.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXU7, Q12525
      UniProtKB/TrEMBL
      A7A0J9, B3LTB7, B5VMP4, C7GND5, C8ZCR5, G2WID8
      Conserved Domains (1) summary
      COG2040
      Location:6 → 324
      MHT1; Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12525.1

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