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    HMLALPHA2 homeodomain mating type protein alpha2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850292, updated on 17-May-2024

    Summary

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    Gene symbol
    HMLALPHA2
    Gene description
    homeodomain mating type protein alpha2
    Primary source
    FungiDB:YCL067C
    Locus tag
    YCL067C
    See related
    SGD:S000000572; AllianceGenome:SGD:S000000572; VEuPathDB:YCL067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ALPHA2
    Summary
    Predicted to enable DNA binding activity, bending; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of mating-type specific transcription from RNA polymerase II promoter. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See HMLALPHA2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (12386..13018, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene basic amino acid transporter Neighboring gene uncharacterized protein Neighboring gene transcriptional co-activator mating type protein alpha Neighboring gene L-serine/L-threonine ammonia-lyase CHA1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mating type control in Saccharomyces cerevisiae: a frameshift mutation at the common DNA sequence, X, of the HML alpha locus. Tanaka K, et al. Mol Cell Biol, 1984 Jan. PMID 6321951, Free PMC Article
    2. Aggregation of the Whi3 protein, not loss of heterochromatin, causes sterility in old yeast cells. Schlissel G, et al. Science, 2017 Mar 17. PMID 28302853, Free PMC Article
    3. Combined analysis of expression data and transcription factor binding sites in the yeast genome. Nagaraj VH, et al. BMC Genomics, 2004 Aug 26. PMID 15331021, Free PMC Article
    4. Ubiquitin-dependent degradation of the yeast Mat(alpha)2 repressor enables a switch in developmental state. Laney JD, et al. Genes Dev, 2003 Sep 15. PMID 12952895, Free PMC Article
    5. Altering the DNA-binding specificity of the yeast Matalpha 2 homeodomain protein. Mathias JR, et al. J Biol Chem, 2001 Aug 31. PMID 11438530

    See all (99) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding, bending ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mating type determination ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homeodomain mating type protein alpha2
    NP_009866.1
    • Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      12386..13018 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178708.1 → NP_009866.1  TPA: homeodomain mating type protein alpha2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQV2, P01367, P01368, P0CY08, P0CY09, Q6B2C0
      UniProtKB/TrEMBL
      A0A6L1A8U8, A6ZTM1, B3LU20, C8Z424, G2WA57
      Conserved Domains (1) summary
      smart00389
      Location:135 → 188
      HOX; Homeodomain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CY08.1
    P0CY09.1

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