SFA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SFA1
Primary source: FungiDB:YDL168W
Locus tag: YDL168W
See related: SGD:S000002327; AllianceGenome:SGD:S000002327; VEuPathDB:YDL168W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADH5
Summary: Enables S-(hydroxymethyl)glutathione dehydrogenase activity; alcohol dehydrogenase (NAD+) activity; and hydroxymethylfurfural reductase (NADH) activity. Involved in amino acid catabolic process to alcohol via Ehrlich pathway; formaldehyde catabolic process; and furaldehyde metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in AMED syndrome; alcohol use disorder; asthma; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (159604..160764)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IDA Inferred from Direct Assay more info	PubMed
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables alcohol dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxymethylfurfural reductase (NADH) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in amino acid catabolic process to alcohol via Ehrlich pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in formaldehyde catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in formaldehyde catabolic process	IEA Inferred from Electronic Annotation more info
involved_in furaldehyde metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase

NP_010113.1

EC 1.1.1.1

EC 1.1.1.284

Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase; formaldehyde dehydrogenase activity is glutathione-dependent; functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

159604..160764

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180228.1 → NP_010113.1 TPA: bifunctional alcohol dehydrogenase/S-(hydroxymethyl)glutathione dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010113.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRI3, P32771

UniProtKB/TrEMBL

A6ZXG2, C7GL16, N1PAL9

Conserved Domains (1) summary

cd08300
Location:10 → 381

alcohol_DH_class_III; class III alcohol dehydrogenases