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    ENV9 Env9p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854420, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ENV9
    Gene description
    Env9p
    Primary source
    FungiDB:YOR246C
    Locus tag
    YOR246C
    See related
    SGD:S000005772; AllianceGenome:SGD:S000005772; VEuPathDB:YOR246C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables oxidoreductase activity. Involved in lipid droplet organization; vacuolar protein processing; and vacuole organization. Located in mitochondrion. Is active in lipid droplet. Used to study Leber congenital amaurosis. Human ortholog(s) of this gene implicated in several diseases, including Leber congenital amaurosis 13; Leber hereditary optic neuropathy; autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; and esophageal cancer (multiple). Orthologous to several human genes including RDH14 (retinol dehydrogenase 14). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ENV9 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (795801..796793, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene NuA4 histone acetyltransferase complex catalytic subunit ESA1 Neighboring gene diacylglycerol O-acyltransferase Neighboring gene Srl1p Neighboring gene anaphase promoting complex subunit 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast ENV9 encodes a conserved lipid droplet (LD) short-chain dehydrogenase involved in LD morphology. Siddiqah IM, et al. Curr Genet, 2017 Dec. PMID 28540421, Free PMC Article
    2. Sequence and analysis of a 26.9 kb fragment from chromosome XV of the yeast Saccharomyces cerevisiae. Boyer J, et al. Yeast, 1996 Dec. PMID 8972580
    3. Yeast mitochondrial protein-protein interactions reveal diverse complexes and disease-relevant functional relationships. Jin K, et al. J Proteome Res, 2015 Feb 6. PMID 25546499
    4. Systematic, genome-wide identification of host genes affecting replication of a positive-strand RNA virus. Kushner DB, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14671320, Free PMC Article
    5. Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis. Lv X, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30414449

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ENV9 encodes a conserved lipid droplet short-chain dehydrogenase involved in lipid droplets morphology.
      Title: Yeast ENV9 encodes a conserved lipid droplet (LD) short-chain dehydrogenase involved in LD morphology.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet HDA PubMed 
    is_active_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Env9p
    NP_014889.3
    • Conserved oxidoreductase involved in lipid droplet morphology; mutant shows defects in CPY processing and vacuolar morphology; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts; homologus to human RDH12 linked to Leber Congenital Amaurosis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      795801..796793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183665.3 → NP_014889.3  TPA: Env9p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014889.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2U8, Q08651
      UniProtKB/TrEMBL
      A0A8H4FAF2, A6ZP85, B3LJR5, N1P3J4
      Conserved Domains (1) summary
      cl21454
      Location:17 → 318
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08651.1

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