SIF2 Sif2p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SIF2
Official Full Name: Sif2p
Primary source: SGD:S000000307
Locus tag: YBR103W
See related: AllianceGenome:SGD:S000000307; FungiDB:YBR103W; VEuPathDB:YBR103W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: EMB1
Summary: Predicted to enable transcription corepressor activity. Involved in negative regulation of meiotic nuclear division; positive regulation of stress-activated MAPK cascade; and regulation of DNA-templated transcription. Located in nucleus. Part of Set3 complex. Human ortholog(s) of this gene implicated in Pierpont syndrome; Y-linked deafness 2; autosomal dominant intellectual developmental disorder 41; and congenital nongoitrous hypothyroidism 8. Orthologous to several human genes including TBL1XR1 (TBL1X/Y related 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SIF2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (447709..449316)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

determined the X-ray crystal structure of a 46 kDa C-terminal domain; this domain contains an unusual eight-bladed beta-propeller structure
Title: The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of meiotic nuclear division	IPI Inferred from Physical Interaction more info	PubMed
involved_in positive regulation of stress-activated MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of primary metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Rpd3L-Expanded complex	HDA more info	PubMed
part_of Set3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Set3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sif2p

NP_009661.1

WD40 repeat-containing subunit of Set3C histone deacetylase complex; complex represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

447709..449316

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178451.1 → NP_009661.1 TPA: Sif2p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009661.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQA2, P38262

UniProtKB/TrEMBL

C7GUK1, G2W9A8, N1PAS8

Conserved Domains (3) summary

sd00039
Location:224 → 259

7WD40; WD40 repeat [structural motif]

pfam08513
Location:7 → 31

LisH

cl29593
Location:220 → 516

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...