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    Tcea2 transcription elongation factor A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29575, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Tcea2provided by RGD
    Official Full Name
    transcription elongation factor A2provided by RGD
    Primary source
    RGD:61825
    See related
    EnsemblRapid:ENSRNOG00000016288 AllianceGenome:RGD:61825
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity and zinc ion binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nucleoplasm. Predicted to be active in nucleus. Orthologous to human TCEA2 (transcription elongation factor A2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 436.9) and Brain (RPKM 162.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tcea2 in Genome Data Viewer
    Location:
    3q43
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (189173756..189181633)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (168796244..168804125)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (177187686..177195898)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101835 Neighboring gene SRY-box transcription factor 18 Neighboring gene regulator of G-protein signaling 19 Neighboring gene LKAAEAR motif containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and identification of testis-specific transcription elongation factor S-II. Xu Q, et al. J Biol Chem, 1994 Jan 28. PMID 8300645
    2. Control of transcriptional elongation. Kwak H, et al. Annu Rev Genet, 2013. PMID 24050178, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein 2
    Names
    testis-specific S-II
    transcription elongation factor A (SII), 2
    transcription elongation factor S-II protein 2
    transcription elongation factor TFIIS.l

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057098.2 → NP_476439.1  transcription elongation factor A protein 2

      See identical proteins and their annotated locations for NP_476439.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q63799
      UniProtKB/TrEMBL
      A0A8L2QBN2
      Related
      ENSRNOP00000112743.1, ENSRNOT00000130150.1
      Conserved Domains (4) summary
      cd00183
      Location:4 → 80
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:252 → 298
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:5 → 299
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:136 → 243
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      189173756..189181633
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006235742.5 → XP_006235804.1  transcription elongation factor A protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2QBN2
      Conserved Domains (4) summary
      cd00183
      Location:4 → 80
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:257 → 303
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:5 → 304
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:141 → 248
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    2. XM_006235740.4 → XP_006235802.1  transcription elongation factor A protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QBN2
      Conserved Domains (4) summary
      cd00183
      Location:35 → 94
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:271 → 317
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:35 → 318
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:155 → 262
      TFIIS_M; Transcription factor S-II (TFIIS), central domain

    3. XM_006235741.4 → XP_006235803.1  transcription elongation factor A protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2QBN2
      Related
      ENSRNOP00000022073.7, ENSRNOT00000022073.9
      Conserved Domains (4) summary
      cd00183
      Location:35 → 94
      TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
      cd13749
      Location:266 → 312
      Zn-ribbon_TFIIS; domain III/zinc ribbon domain of Transcription Factor IIS
      TIGR01385
      Location:35 → 313
      TFSII; transcription elongation factor S-II
      pfam07500
      Location:150 → 257
      TFIIS_M; Transcription factor S-II (TFIIS), central domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63799.1 GenPept UniProtKB/Swiss-Prot:Q63799

    Gene LinkOut

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