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    Stambp Stam binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171565, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Stambpprovided by RGD
    Official Full Name
    Stam binding proteinprovided by RGD
    Primary source
    RGD:619963
    See related
    EnsemblRapid:ENSRNOG00000012227 AllianceGenome:RGD:619963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Amsh
    Summary
    Predicted to enable Lys63-specific deubiquitinase activity; protein domain specific binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in negative regulation of Ras protein signal transduction; negative regulation of phosphatidylinositol 3-kinase signaling; and protein K63-linked deubiquitination. Predicted to act upstream of or within mitotic cytokinesis; negative regulation of neuron apoptotic process; and protein deubiquitination. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cleavage furrow and endosome. Orthologous to human STAMBP (STAM binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 37.2), Kidney (RPKM 27.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (117613730..117642163, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (116055563..116083563, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (115249343..115277340, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene deoxyguanosine kinase Neighboring gene uncharacterized LOC120102320 Neighboring gene actin gamma 2, smooth muscle Neighboring gene uncharacterized LOC120102321 Neighboring gene C-type lectin domain family 4, member F Neighboring gene CD207 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. McDonell LM, et al. Nat Genet, 2013 May. PMID 23542699, Free PMC Article
    2. AMSH is required to degrade ubiquitinated proteins in the central nervous system. Suzuki S, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531206
    3. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Ishii N, et al. Mol Cell Biol, 2001 Dec. PMID 11713295, Free PMC Article
    4. Structural basis for autoinhibition of ESCRT-III CHMP3. Lata S, et al. J Mol Biol, 2008 May 9. PMID 18395747, Free PMC Article
    5. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. Itoh F, et al. EMBO J, 2001 Aug 1. PMID 11483516, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Modulatory role of alpha-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake.
      Title: Modulatory role of α-MSH in hippocampal-dependent memory impairment, synaptic plasticity changes, oxidative stress, and astrocyte reactivity induced by short-term high-fat diet intake.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables K63-linked deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of hippocampal neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    STAM-binding protein
    Names
    associated molecule with the SH3 domain of STAM
    NP_612540.1
    XP_006236788.1
    XP_006236789.1
    XP_038962914.1
    XP_038962915.1
    XP_063141530.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138531.2 → NP_612540.1  STAM-binding protein

      See identical proteins and their annotated locations for NP_612540.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061711
      UniProtKB/Swiss-Prot
      Q8R424
      UniProtKB/TrEMBL
      A6IAN4, A6IAN6
      Related
      ENSRNOP00000014708.3, ENSRNOT00000014708.7
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 115
      USP8_dimer; USP8 dimerization domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      117613730..117642163 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006236726.5 → XP_006236788.1  STAM-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006236788.1

      UniProtKB/Swiss-Prot
      Q8R424
      UniProtKB/TrEMBL
      A6IAN4, A6IAN6
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 115
      USP8_dimer; USP8 dimerization domain

    2. XM_039106986.2 → XP_038962914.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q8R424
      UniProtKB/TrEMBL
      A6IAN4, A6IAN6
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 115
      USP8_dimer; USP8 dimerization domain

    3. XM_039106987.2 → XP_038962915.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q8R424
      UniProtKB/TrEMBL
      A6IAN4, A6IAN6
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 115
      USP8_dimer; USP8 dimerization domain

    4. XM_006236727.5 → XP_006236789.1  STAM-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006236789.1

      UniProtKB/Swiss-Prot
      Q8R424
      UniProtKB/TrEMBL
      A6IAN4, A6IAN6
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 115
      USP8_dimer; USP8 dimerization domain

    5. XM_063285460.1 → XP_063141530.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q8R424
      UniProtKB/TrEMBL
      A6IAN4, A6IAN6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R424.1 GenPept UniProtKB/Swiss-Prot:Q8R424

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