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    Crip1 cysteine rich protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691657, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Crip1provided by RGD
    Official Full Name
    cysteine rich protein 1provided by RGD
    Primary source
    RGD:1597237
    See related
    EnsemblRapid:ENSRNOG00000027990 AllianceGenome:RGD:1597237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crip; Crp-1
    Summary
    Predicted to enable peptide binding activity and zinc ion binding activity. Predicted to be involved in several processes, including cellular response to UV-B; intrinsic apoptotic signaling pathway in response to DNA damage; and prostate gland stromal morphogenesis. Predicted to be located in cytoplasm. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 755.9), Thymus (RPKM 591.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    6q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (138047801..138055672)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (132226746..132234620)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137959171..137967042)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 Neighboring gene cysteine-rich protein 2 Neighboring gene tubulin epsilon and delta complex 1 Neighboring gene transmembrane protein 121

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the cysteine-rich intestinal protein, CRIP. Pérez-Alvarado GC, et al. J Mol Biol, 1996 Mar 22. PMID 8632452
    2. Cloning and initial characterization of the promoter region of the rat cysteine-rich intestinal protein gene. Levenson CW, et al. Biochem J, 1994 Nov 1. PMID 7980439, Free PMC Article
    3. Overexpression of CRIP in transgenic mice alters cytokine patterns and the immune response. Lanningham-Foster L, et al. Am J Physiol Endocrinol Metab, 2002 Jun. PMID 12006348
    4. Cysteine-rich intestinal protein binds zinc during transmucosal zinc transport. Hempe JM, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946385, Free PMC Article
    5. Identification and rational redesign of peptide ligands to CRIP1, a novel biomarker for cancers. Hao J, et al. PLoS Comput Biol, 2008 Aug 1. PMID 18670594, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to UV-B ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to UV-B ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cellular response to antibiotic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to antibiotic ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in prostate gland stromal morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to zinc ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine-rich protein 1
    Names
    cysteine-rich intestinal protein
    cysteine-rich protein 1 (intestinal)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134933.2 → NP_001128405.1  cysteine-rich protein 1

      See identical proteins and their annotated locations for NP_001128405.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI716760, CB729209
      UniProtKB/Swiss-Prot
      P63255
      UniProtKB/TrEMBL
      A6KBZ1
      Related
      ENSRNOP00000006835.3, ENSRNOT00000006835.7
      Conserved Domains (1) summary
      cd09478
      Location:4 → 57
      LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)

    2. NM_001244867.1 → NP_001231796.1  cysteine-rich protein 1

      See identical proteins and their annotated locations for NP_001231796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI716760, FQ223262
      UniProtKB/Swiss-Prot
      P63255
      UniProtKB/TrEMBL
      A6KBZ1
      Conserved Domains (1) summary
      cd09478
      Location:4 → 57
      LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      138047801..138055672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262530.1 → XP_063118600.1  cysteine-rich protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P63255
      UniProtKB/TrEMBL
      A6KBZ1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63255.2 GenPept UniProtKB/Swiss-Prot:P63255

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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