U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ampd2 adenosine monophosphate deaminase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362015, updated on 10-Jul-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ampd2provided by RGD
    Official Full Name
    adenosine monophosphate deaminase 2provided by RGD
    Primary source
    RGD:2110
    See related
    EnsemblRapid:ENSRNOG00000019240 AllianceGenome:RGD:2110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ampd
    Summary
    Predicted to enable AMP deaminase activity and identical protein binding activity. Predicted to be involved in ATP metabolic process and purine nucleotide metabolic process. Predicted to act upstream of or within several processes, including cholesterol homeostasis; energy homeostasis; and glomerular visceral epithelial cell development. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 63 and pontocerebellar hypoplasia type 9. Orthologous to human AMPD2 (adenosine monophosphate deaminase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 142.1), Kidney (RPKM 94.2) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ampd2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198395767..198408514, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195707609..195720454, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210861624..210874348, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA71 Neighboring gene glutathione S-transferase mu 4 Neighboring gene small nucleolar RNA SNORD47 Neighboring gene G protein subunit alpha transducin 2 Neighboring gene G protein subunit alpha i3 Neighboring gene RNA, U6 small nuclear 318

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A mutation in Ampd2 is associated with nephrotic syndrome and hypercholesterolemia in mice. Helmering J, et al. Lipids Health Dis, 2014 Oct 31. PMID 25361754, Free PMC Article
    2. Proteinuria in AMPD2-deficient mice. Toyama K, et al. Genes Cells, 2012 Jan. PMID 22212473
    3. Adenylate deaminase. A multigene family in humans and rats. Morisaki T, et al. J Biol Chem, 1990 Jul 15. PMID 2365682
    4. Regulation of rat AMP deaminase 3 (isoform C) by development and skeletal muscle fibre type. Mahnke-Zizelman DK, et al. Biochem J, 1997 Sep 1. PMID 9291127, Free PMC Article
    5. AMPD2 regulates GTP synthesis and is mutated in a potentially treatable neurodegenerative brainstem disorder. Akizu N, et al. Cell, 2013 Aug 1. PMID 23911318, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables AMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in AMP metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in AMP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GTP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within IMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in IMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in IMP salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cyclic purine nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cyclic purine nucleotide metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within energy homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within podocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    AMP deaminase 2
    Names
    adenosine monophosphate deaminase 2 (isoform L)
    NP_001095151.1
    XP_006233230.4
    XP_006233231.1
    XP_008759629.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101681.2 → NP_001095151.1  AMP deaminase 2

      See identical proteins and their annotated locations for NP_001095151.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166402
      UniProtKB/Swiss-Prot
      B2GUT6, Q02356
      UniProtKB/TrEMBL
      A6HUX6
      Related
      ENSRNOP00000026051.5, ENSRNOT00000026051.7
      Conserved Domains (1) summary
      cd01319
      Location:301 → 797
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198395767..198408514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233168.4 → XP_006233230.4  AMP deaminase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3U1
      Related
      ENSRNOP00000105424.1, ENSRNOT00000169239.1

    2. XM_006233169.5 → XP_006233231.1  AMP deaminase 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K3U1
      Related
      ENSRNOP00000072776.1, ENSRNOT00000088657.3
      Conserved Domains (2) summary
      PLN03055
      Location:172 → 774
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:275 → 771
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.

    3. XM_008761407.4 → XP_008759629.1  AMP deaminase 2 isoform X2

      Conserved Domains (2) summary
      PLN03055
      Location:174 → 776
      PLN03055; AMP deaminase; Provisional
      cd01319
      Location:277 → 773
      AMPD; AMP deaminase (AMPD) catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) at position 6 of the adenine nucleotide ring. AMPD is a diverse and highly regulated eukaryotic key enzyme of the adenylate catabolic pathway.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02356.2 GenPept UniProtKB/Swiss-Prot:Q02356

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous