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    Nudt18 nudix hydrolase 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361068, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Nudt18provided by RGD
    Official Full Name
    nudix hydrolase 18provided by RGD
    Primary source
    RGD:1311802
    See related
    EnsemblRapid:ENSRNOG00000011831 AllianceGenome:RGD:1311802
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311802
    Summary
    Predicted to enable magnesium ion binding activity and nucleoside-diphosphatase activity. Predicted to be involved in GDP catabolic process; dADP catabolic process; and dGDP catabolic process. Orthologous to human NUDT18 (nudix hydrolase 18). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 211.5), Heart (RPKM 114.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nudt18 in Genome Data Viewer
    Location:
    15p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52060297..52062822)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45650597..45653985)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52265557..52268081)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene receptor accessory protein 4 Neighboring gene HR upstream open reading frame Neighboring gene HR, lysine demethylase and nuclear receptor corepressor Neighboring gene FHF complex subunit HOOK interacting protein 2B Neighboring gene dematin actin binding protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2. Takagi Y, et al. J Biol Chem, 2012 Jun 15. PMID 22556419, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 8-hydroxy-dADP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 8-hydroxy-dADP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 8-oxo-GDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-GDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 8-oxo-GDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 8-oxo-dGDP phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dADP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dADP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dGDP catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dGDP catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    8-oxo-dGDP phosphatase NUDT18
    Names
    2-hydroxy-dADP phosphatase
    7,8-dihydro-8-oxoguanine phosphatase
    mutT homolog 3
    nucleoside diphosphate-linked moiety X motif 18
    nudix (nucleoside diphosphate linked moiety X)-type motif 18
    nudix motif 18
    NP_001094202.1
    XP_038949443.1
    XP_038949444.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100732.1 → NP_001094202.1  8-oxo-dGDP phosphatase NUDT18

      See identical proteins and their annotated locations for NP_001094202.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158874
      UniProtKB/Swiss-Prot
      Q4KM80, Q641Y7
      UniProtKB/TrEMBL
      B0BNL9
      Related
      ENSRNOP00000015969.4, ENSRNOT00000015969.8
      Conserved Domains (1) summary
      cd04671
      Location:44 → 166
      Nudix_Hydrolase_13; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      52060297..52062822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039093516.2 → XP_038949444.1  8-oxo-dGDP phosphatase NUDT18 isoform X2

      Conserved Domains (1) summary
      cl00447
      Location:1 → 108
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    2. XM_039093515.2 → XP_038949443.1  8-oxo-dGDP phosphatase NUDT18 isoform X1

      Conserved Domains (1) summary
      cl00447
      Location:14 → 126
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641Y7.2 GenPept UniProtKB/Swiss-Prot:Q641Y7

    Gene LinkOut

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