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    Ninl ninein-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311529, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Ninlprovided by RGD
    Official Full Name
    ninein-likeprovided by RGD
    Primary source
    RGD:1306152
    See related
    EnsemblRapid:ENSRNOG00000027747 AllianceGenome:RGD:1306152
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nlp; RGD1306152
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in microtubule anchoring at centrosome. Predicted to be located in cytosol; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in centrosome. Orthologous to human NINL (ninein like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 94.1), Testes (RPKM 71.9) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ninl in Genome Data Viewer
    Location:
    3q41
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160208757..160275077, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (139748353..139814683, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (146719210..146785450, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene GINS complex subunit 1 Neighboring gene activator of basal transcription 1, pseudogene 2 Neighboring gene RNA, U6 small nuclear 722 Neighboring gene uncharacterized LOC134486182 Neighboring gene uncharacterized LOC134486183 Neighboring gene N-acetylneuraminic acid phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in microtubule anchoring at centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ninein-like; ninein-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430466.1 → NP_001417395.1  ninein-like

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      D4A5N1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      160208757..160275077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762394.4 → XP_008760616.2  ninein-like protein isoform X2

      Related
      ENSRNOP00000101786.1, ENSRNOT00000166583.1
      Conserved Domains (3) summary
      COG1196
      Location:1058 → 1387
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:462 → 1340
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:199 → 260
      EF-hand_7; EF-hand domain pair

    2. XM_039106651.2 → XP_038962579.1  ninein-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2X1, A0A8I6A773
      Related
      ENSRNOP00000088771.1, ENSRNOT00000116558.2
      Conserved Domains (3) summary
      COG1196
      Location:1096 → 1425
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:340 → 913
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:199 → 260
      EF-hand_7; EF-hand domain pair

    3. XM_063285077.1 → XP_063141147.1  ninein-like protein isoform X3

      Related
      ENSRNOP00000100824.1, ENSRNOT00000163129.1

    4. XM_039106654.2 → XP_038962582.1  ninein-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8I6A2X1
      Related
      ENSRNOP00000061689.4, ENSRNOT00000068689.5
      Conserved Domains (3) summary
      COG1196
      Location:1041 → 1370
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:291 → 858
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:199 → 260
      EF-hand_7; EF-hand domain pair

    5. XM_039106653.2 → XP_038962581.1  ninein-like protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2X1, A0A8I6A773
      Conserved Domains (3) summary
      COG1196
      Location:1096 → 1425
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:340 → 913
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam13499
      Location:199 → 260
      EF-hand_7; EF-hand domain pair

    6. XM_063285079.1 → XP_063141149.1  ninein-like protein isoform X6

    7. XM_039106657.2 → XP_038962585.1  ninein-like protein isoform X5

      Conserved Domains (4) summary
      PRK13589
      Location:27 → 85
      PRK13589; flagellin A
      PHA03378
      Location:647 → 811
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:824 → 1115
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:68 → 641
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    Nucleotide Protein Strain
    Heading Accession and Version

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