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    Fcsk fucose kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307848, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Fcskprovided by RGD
    Official Full Name
    fucose kinaseprovided by RGD
    Primary source
    RGD:1307000
    See related
    EnsemblRapid:ENSRNOG00000059453 AllianceGenome:RGD:1307000
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fuk
    Summary
    Predicted to enable fucokinase activity. Involved in response to dopamine. Orthologous to human FCSK (fucose kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 57.8), Kidney (RPKM 57.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    19q12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (55743746..55783873, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (38849130..38874497, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (43338146..43357826)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 3 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene small nucleolar RNA, C/D box 111B Neighboring gene component of oligomeric golgi complex 4 Neighboring gene uncharacterized LOC134483368 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Dopamine stimulated L-fucose incorporation into brain proteins is related to an increase in fucokinase activity. Jork R, et al. Biomed Biochim Acta, 1984. PMID 6331424
    2. Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation. Ng BG, et al. Am J Hum Genet, 2018 Dec 6. PMID 30503518, Free PMC Article
    3. Cloning and expression of murine enzymes involved in the salvage pathway of GDP-L-fucose. Niittymäki J, et al. Eur J Biochem, 2004 Jan. PMID 14686921
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fucokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-L-fucose salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-L-fucose salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to dopamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-fucose kinase
    Names
    fucokinase
    NP_001382075.1
    XP_038953694.1
    XP_038953696.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395146.1 → NP_001382075.1  L-fucose kinase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A0G2JVI4, A6IZ73
      Related
      ENSRNOP00000069496.2, ENSRNOT00000091720.3
      Conserved Domains (2) summary
      PRK13412
      Location:664 → 1047
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:97 → 496
      Fucokinase; L-fucokinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      55743746..55783873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097766.2 → XP_038953694.1  L-fucose kinase isoform X1

      UniProtKB/TrEMBL
      A6IZ73
      Related
      ENSRNOP00000101537.1, ENSRNOT00000138498.1
      Conserved Domains (2) summary
      PRK13412
      Location:664 → 1047
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:97 → 496
      Fucokinase; L-fucokinase

    2. XM_039097768.2 → XP_038953696.1  L-fucose kinase isoform X2

      Conserved Domains (2) summary
      PRK13412
      Location:376 → 759
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:1 → 208
      Fucokinase; L-fucokinase

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107429.1: Suppressed sequence

      Description
      NM_001107429.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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