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    Tes testin LIM domain protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500040, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Tesprovided by RGD
    Official Full Name
    testin LIM domain proteinprovided by RGD
    Primary source
    RGD:1566346
    See related
    EnsemblRapid:ENSRNOG00000051952 AllianceGenome:RGD:1566346
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in cytosol; focal adhesion; and plasma membrane. Predicted to be part of protein-containing complex. Orthologous to human TES (testin LIM domain protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 777.8), Uterus (RPKM 251.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tes in Genome Data Viewer
    Location:
    4q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (46331257..46369782)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (45365304..45403829)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (44321883..44360407)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486669 Neighboring gene uncharacterized LOC120102238 Neighboring gene uncharacterized LOC102550644 Neighboring gene caveolin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The TES gene at 7q31.1 is methylated in tumours and encodes a novel growth-suppressing LIM domain protein. Tobias ES, et al. Oncogene, 2001 May 17. PMID 11420696
    2. AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contacts. Rotter B, et al. Biochem J, 2005 Jun 1. PMID 15656790, Free PMC Article
    3. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. Boëda B, et al. J Biol Chem, 2011 Apr 1. PMID 21278383, Free PMC Article
    4. Comparative analyses of multi-species sequences from targeted genomic regions. Thomas JW, et al. Nature, 2003 Aug 14. PMID 12917688
    5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
      Title: Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testin
    Names
    testis derived transcript

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039344.2 → NP_001034433.1  testin

      Status: PROVISIONAL

      Source sequence(s)
      BC129069
      UniProtKB/Swiss-Prot
      Q2LAP6
      UniProtKB/TrEMBL
      A0A8I6AV73, A6IE14
      Related
      ENSRNOP00000070338.1, ENSRNOT00000091095.3
      Conserved Domains (4) summary
      cd09413
      Location:234 → 291
      LIM1_Testin; The first LIM domain of Testin
      cd09416
      Location:297 → 352
      LIM2_Testin; The second LIM domain of Testin
      cd09419
      Location:359 → 417
      LIM3_Testin; The third LIM domain of Testin
      cd09829
      Location:109 → 196
      PET_testin; The PET domain of Testin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      46331257..46369782
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2LAP6.1 GenPept UniProtKB/Swiss-Prot:Q2LAP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools