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    Myo18a myosin XVIIIa [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360570, updated on 10-Jul-2024

    Summary

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    Symbol
    Myo18aprovided by RGD
    Full Name
    myosin XVIIIaprovided by RGD
    Primary source
    RGD:1562698
    See related
    EnsemblRapid:ENSRNOG00000033101 AllianceGenome:RGD:1562698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ADP binding activity; ATP binding activity; and actin filament binding activity. Predicted to be involved in several processes, including asymmetric Golgi ribbon formation; positive regulation of transport; and regulation of macrophage activation. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in several cellular components, including actomyosin; brush border; and trans-Golgi network. Predicted to be part of myosin complex. Orthologous to human MYO18A (myosin XVIIIA). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 284.9), Heart (RPKM 211.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myo18a in Genome Data Viewer
    Location:
    10q24
    Exon count:
    53
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (63152303..63253543)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (62654218..62755465)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (64979770..65080535, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene crystallin, beta A1 Neighboring gene bolA family member 2, pseudogene 5 Neighboring gene uncharacterized LOC102557169 Neighboring gene uncharacterized LOC102551552 Neighboring gene pipecolic acid and sarcosine oxidase Neighboring gene uncharacterized LOC134480828 Neighboring gene seizure related 6 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation of a novel PDZ-containing myosin from hematopoietic supportive bone marrow stromal cell lines. Furusawa T, et al. Biochem Biophys Res Commun, 2000 Apr 2. PMID 10733906
    2. Functional characterization of human myosin-18A and its interaction with F-actin and GOLPH3. Taft MH, et al. J Biol Chem, 2013 Oct 18. PMID 23990465, Free PMC Article
    3. Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A. Yang CH, et al. J Biol Chem, 2005 Oct 14. PMID 16087679, Free PMC Article
    4. GOLPH3L antagonizes GOLPH3 to determine Golgi morphology. Ng MM, et al. Mol Biol Cell, 2013 Mar. PMID 23345592, Free PMC Article
    5. GOLPH3 bridges phosphatidylinositol-4- phosphate and actomyosin to stretch and shape the Golgi to promote budding. Dippold HC, et al. Cell, 2009 Oct 16. PMID 19837035, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ADP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi vesicle budding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi vesicle budding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actomyosin structure organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asymmetric Golgi ribbon formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in asymmetric Golgi ribbon formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of opsonization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of opsonization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actomyosin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actomyosin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-XVIIIa
    Names
    basic salivary proline-rich protein 1-like
    basic salivary proline-rich protein 2-like
    myosin 18a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172137.3 → NP_001165608.2  unconventional myosin-XVIIIa isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HGZ1
      Conserved Domains (3) summary
      COG5022
      Location:381 → 1905
      COG5022; Myosin heavy chain [General function prediction only]
      cd00992
      Location:220 → 308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01386
      Location:419 → 1173
      MYSc_Myo18; class XVIII myosin, motor domain

    2. NM_001415683.1 → NP_001402612.1  unconventional myosin-XVIIIa isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HGZ1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      63152303..63253543
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269370.1 → XP_063125440.1  unconventional myosin-XVIIIa isoform X21

      UniProtKB/TrEMBL
      A0A8I6A2X3, A6HGZ1

    2. XM_063269371.1 → XP_063125441.1  unconventional myosin-XVIIIa isoform X22

      UniProtKB/TrEMBL
      A0A8I5Y6H7
      Related
      ENSRNOP00000077922.2, ENSRNOT00000095502.2

    3. XM_063269373.1 → XP_063125443.1  unconventional myosin-XVIIIa isoform X24

      UniProtKB/TrEMBL
      A6HGZ1

    4. XM_063269374.1 → XP_063125444.1  unconventional myosin-XVIIIa isoform X25

      UniProtKB/TrEMBL
      A6HGZ1

    5. XM_063269376.1 → XP_063125446.1  unconventional myosin-XVIIIa isoform X27

      UniProtKB/TrEMBL
      A6HGZ1

    6. XM_063269372.1 → XP_063125442.1  unconventional myosin-XVIIIa isoform X23

      UniProtKB/TrEMBL
      A0A0G2JY08, A6HGZ1
      Related
      ENSRNOP00000097807.2, ENSRNOT00000100376.2

    7. XM_063269375.1 → XP_063125445.1  unconventional myosin-XVIIIa isoform X26

      UniProtKB/TrEMBL
      A0A8I6ATN3
      Related
      ENSRNOP00000070473.3, ENSRNOT00000088919.3

    8. XM_039086333.2 → XP_038942261.1  unconventional myosin-XVIIIa isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6H7
      Conserved Domains (4) summary
      COG5022
      Location:429 → 1960
      COG5022; Myosin heavy chain [General function prediction only]
      cd00992
      Location:220 → 308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01386
      Location:467 → 1228
      MYSc_Myo18; class XVIII myosin, motor domain
      NF033777
      Location:1876 → 2073
      M_group_A_cterm; M protein C-terminal domain

    9. XM_039086335.2 → XP_038942263.1  unconventional myosin-XVIIIa isoform X8

      UniProtKB/TrEMBL
      A0A8I5Y6H7
      Conserved Domains (4) summary
      COG5022
      Location:393 → 1924
      COG5022; Myosin heavy chain [General function prediction only]
      cd00992
      Location:220 → 308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01386
      Location:431 → 1192
      MYSc_Myo18; class XVIII myosin, motor domain
      NF033777
      Location:1840 → 2037
      M_group_A_cterm; M protein C-terminal domain

    10. XM_039086337.2 → XP_038942265.1  unconventional myosin-XVIIIa isoform X9

      UniProtKB/TrEMBL
      A0A8I5Y6H7
      Conserved Domains (4) summary
      COG5022
      Location:381 → 1912
      COG5022; Myosin heavy chain [General function prediction only]
      cd00992
      Location:220 → 308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd01386
      Location:419 → 1180
      MYSc_Myo18; class XVIII myosin, motor domain
      NF033777
      Location:1828 → 2025
      M_group_A_cterm; M protein C-terminal domain

    11. XM_063269361.1 → XP_063125431.1  unconventional myosin-XVIIIa isoform X10

      UniProtKB/TrEMBL
      A6HGZ1

    12. XM_063269362.1 → XP_063125432.1  unconventional myosin-XVIIIa isoform X11

      UniProtKB/TrEMBL
      A0A8I6ATN3
      Related
      ENSRNOP00000080654.2, ENSRNOT00000098495.2

    13. XM_063269363.1 → XP_063125433.1  unconventional myosin-XVIIIa isoform X12

      UniProtKB/TrEMBL
      A0A8I6ATN3

    14. XM_063269359.1 → XP_063125429.1  unconventional myosin-XVIIIa isoform X6

      UniProtKB/TrEMBL
      A0A8I5Y6H7

    15. XM_039086344.2 → XP_038942272.1  unconventional myosin-XVIIIa isoform X15

      UniProtKB/TrEMBL
      A0A8I6AAE3
      Conserved Domains (3) summary
      COG5022
      Location:50 → 1581
      COG5022; Myosin heavy chain [General function prediction only]
      cd01386
      Location:88 → 849
      MYSc_Myo18; class XVIII myosin, motor domain
      NF033777
      Location:1497 → 1694
      M_group_A_cterm; M protein C-terminal domain

    16. XM_063269365.1 → XP_063125435.1  unconventional myosin-XVIIIa isoform X16

      UniProtKB/TrEMBL
      A0A8I6AAE3

    17. XM_039086340.2 → XP_038942268.1  unconventional myosin-XVIIIa isoform X14

      UniProtKB/TrEMBL
      A0A8I6AAE3
      Conserved Domains (3) summary
      COG5022
      Location:62 → 1593
      COG5022; Myosin heavy chain [General function prediction only]
      cd01386
      Location:100 → 861
      MYSc_Myo18; class XVIII myosin, motor domain
      NF033777
      Location:1509 → 1706
      M_group_A_cterm; M protein C-terminal domain

    18. XM_063269360.1 → XP_063125430.1  unconventional myosin-XVIIIa isoform X7

      UniProtKB/TrEMBL
      A0A8I6A163
      Related
      ENSRNOP00000084388.1, ENSRNOT00000102240.2

    19. XM_063269353.1 → XP_063125423.1  unconventional myosin-XVIIIa isoform X1

      UniProtKB/TrEMBL
      A0A8I6AAE3

    20. XM_063269354.1 → XP_063125424.1  unconventional myosin-XVIIIa isoform X2

      UniProtKB/TrEMBL
      A0A8I6AAE3

    21. XM_063269358.1 → XP_063125428.1  unconventional myosin-XVIIIa isoform X5

      UniProtKB/TrEMBL
      A0A8I6AAE3

    22. XM_063269355.1 → XP_063125425.1  unconventional myosin-XVIIIa isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAE3

    23. XM_063269357.1 → XP_063125427.1  unconventional myosin-XVIIIa isoform X4

      UniProtKB/TrEMBL
      A0A8I6AAE3

    24. XM_063269364.1 → XP_063125434.1  unconventional myosin-XVIIIa isoform X13

      UniProtKB/TrEMBL
      A0A8I6A9C6

    25. XM_063269366.1 → XP_063125436.1  unconventional myosin-XVIIIa isoform X17

      UniProtKB/TrEMBL
      A0A8I6A9C6

    26. XM_063269367.1 → XP_063125437.1  unconventional myosin-XVIIIa isoform X18

      UniProtKB/TrEMBL
      A0A8I6A9C6

    27. XM_063269368.1 → XP_063125438.1  unconventional myosin-XVIIIa isoform X19

      UniProtKB/TrEMBL
      A0A8I6A9C6

    28. XM_063269369.1 → XP_063125439.1  unconventional myosin-XVIIIa isoform X20

      UniProtKB/TrEMBL
      A0A8I6A9C6

    29. XM_063269377.1 → XP_063125447.1  unconventional myosin-XVIIIa isoform X28

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZFD0.2 GenPept UniProtKB/Swiss-Prot:D3ZFD0

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